Search for dissertations about: "dynamic covalent kinetic combinatorial resolution"

Found 3 swedish dissertations containing the words dynamic covalent kinetic combinatorial resolution.

  2. 1. Dynamic Covalent Resolution: Applications in System Screening and Asymmetric Synthesis

    Author : Pornrapee Vongvilai; Olof Ramström; Benjamin Miller; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; dynamic covalent kinetic combinatorial resolution; Self-screening; Transesterification; Amidation; Enzyme catalysis; Nitroaldol reaction; Secondary alcohols; Strecker reaction; Aminonitriles; Racemase; Enzyme catalytic promiscuity; Chemistry; Kemi; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Abstract : Combined thermodynamic/kinetic events amount to a kinetically controlled Dynamic Combinatorial Resolution (DCR) process, where the lability of themolecules/aggregates are used to generate dynamics, and the species experiencing the lowest activation energy is selected via kinetic process. Bothinter- and intramolecular processes can be performed using this concept,resulting in complete resolution and associated amplification of the selected species. READ MORE

  4. 2. Dynamic Systems for Screening, Control and Identification of Protein-Ligand Interactions

    Author : Rikard Larsson; Olof Ramström; Michel R. Gagné; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dynamic combinatorial chemistry; Dynamic kinetic combinatorial resolution; Catalytic screening; Transthiolesterification; Thiol disulfide interchange; Nitroaldol reaction; Lectins; Hydrolases; Dynamic self-inhibition; Organic chemistry; Organisk kemi;

    Abstract : Dynamic systems for screening, control and identification of different protein-ligand interactions are presented. Dynamic chemistry is used to produce new compounds/constituents in situ that can interact with a target molecule. Several entities can be introduced at the same time and interact with one another. READ MORE

  5. 3. Dynamic Systems: Evaluation, Screening and Synthetic Application

    Author : Morakot Sakulsombat; Olof Ramström; Ulrich Lüning; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; constitutional dynamic chemistry; dynamic combinatorial chemistry resolution; dynamic fragment-based approach; dynamic kinetic resolution; dynamic reversible systems; 1H STD-NMR; multicomponent reaction; tandem reaction; Organic chemistry; Organisk kemi;

    Abstract : The research work reported in the thesis deals with the development of dynamic covalent systems and their applications in evaluation and screening of protein-ligands and enzyme inhibitors, as well as in synthetic methodologies. The thesis is divided into four parts as described below. READ MORE