Search for dissertations about: "dyskinesias"

Showing result 1 - 5 of 16 swedish dissertations containing the word dyskinesias.

  2. 1. Cell and Gene Therapy for Parkinson's Disease: Therapeutic Effect and Modulation of Dyskinesias in the 6-OHDA Rat Model

    Author : Thomas Carlsson; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Pharmacological sciences; pharmacognosy; pharmacy; neurofysiologi; Medicin människa och djur ; Neurology; neuropsychology; neurophysiology; Neurologi; Medicine human and vertebrates ; Parkinson?s disease; Serotonin; Tyrosine hydroxylase; Ventral mesenchephalon; Motor behavior; L-DOPA; GTP cyclohydrolase 1; Gene therapy; Dyskinesias; Cell transplantation; Dopamine; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : The main pathological feature in Parkinson's disease is the progressive loss of dopamine neurons in the midbrain, which in turn leads to the appearance of motor deficits such as akinesia/bradykinesia (loss/slowness of movements), rigidity, postural imbalance and tremor. To this day, there is no cure for the disease, but there are medications to relieve the symptoms. READ MORE

  4. 2. Dopamine and the regulation of movements - significance of nigral and striatal dopamine release in normal, hemiparkinsonian and dyskinetic rats

    Author : Daniel Andersson; Göteborgs universitet; []
    Keywords : dopamine; substantia nigra; striatum; L-DOPA; dyskinesias; serotonin;

    Abstract : Introduction: The nigrostriatal dopamine (DA) containing neurones are a pivotal component in the basal ganglia, a network that regulates movement. Degeneration of these neurones causes the cardinal symptoms of Parkinson’s disease (PD). READ MORE

  5. 3. Assessment of Graft Effects and Function in Cell Replacement Therapy for Parkinson's Disease

    Author : Peter Hagell; Äldres hälsa och personcentrerad vård; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; measurement; psychometrics; perceived health; dyskinesias; assessment; striatum; positron emission tomography; dopamine; Parkinson s disease; transplantation;

    Abstract : This explorative study aimed to apply, develop, and evaluate assessment methods at various levels in cell replacement therapy for Parkinson’s disease (PD). Observed motor effects in five grafted patients support that timed motor tasks and clinical ratings of parkinsonism are able to monitor motor function, but their psychometric properties need further attention. READ MORE

  6. 4. Levodopa- and Neuroleptic-Induced Dyskinesias : Studies on Pharmacological Modification and Processing of Opioid Neuropeptides

    Author : Rebecka Klintenberg; Alan Crossman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Opioid peptides; dyskinesia; Parkinson s disease; mass spectrometry; metabolism; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning; biologisk beroendeforskning; Biological Research on Drug Dependence;

    Abstract : Dyskinesias or abnormal involuntary movements are a debilitating complication of long-term levodopa treatment of Parkinson’s disease (PD) that is widely experienced and may compromise the efficacy of the drug therapy. Tardive dyskinesia is another important adverse effect seen with antipsychotic drug treatment. READ MORE

  7. 5. Emerging pharmacotherapies for Parkinson's Disease: Experimental studies in the rat

    Author : Hanna Iderberg; Basala gangliernas patofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; L-DOPA; L-DOPA-induced dyskinesia; rat model of Parkinson s disease; behavioural pharmacology;

    Abstract : Parkinson´s disease (PD) is a neurodegenerative disorder characterized by the typical motor symptoms, akinesia/bradykinesia, rigidity and resting tremor. These symptoms are caused by a deficiency of dopamine (DA) in the brain, which depends on degeneration of DA neurons in the substantia nigra. READ MORE