Search for dissertations about: "eNOS hypertension"

Found 5 swedish dissertations containing the words eNOS hypertension.

  2. 1. The interplay between the endocrine and cardiovascular systems. A study of the hormonal influence on cardiovascular function and endothelial nitric oxide synthase (eNOS) expression

    Author : Anna Wickman; Göteborgs universitet; []
    Keywords : hypophysectomy · growth hormone · insulin-like growth factor-I · estrogen · vascular reactivity · endothelial function · endothelial nitric oxide synthase · nitric oxide · cardiovascular function · vasculature · kidney · hypertension;

    Abstract : During the present thesis, special interest was focused on the cardiovascular effects of growth hormone (GH) and estrogen (E2) and combined treatment of GH+E2, in particular the possible effects on endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) bioavailability for maintaining cardiovascular homeostasis. The possible role of fluid mechanical force e. READ MORE

  4. 2. NADPH oxidase and xanthine oxidoreductase as targets and regulators of the nitrate-nitrite-nitric oxide pathway

    Author : Maria Peleli; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Overproduction of reactive oxygen species (ROS) by NADPH oxidase (NOX) and xanthine oxidoreductase (XOR) with a concomitant decrease in the bioavailability of nitric oxide (NO) from eNOS contributes to the development of cardiovascular and metabolic disorders. Extensive research has proven the existence of an alternative NOS-independent pathway for NO production. READ MORE

  5. 3. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

    Author : Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

    Abstract : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. READ MORE

  6. 4. Nitric oxide in cardiovascular and renal disease : role of organic nitrates, inorganic nitrate and red blood cells

    Author : Zhengbing Zhuge; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : RATIONALE: Cardiovascular and renal disorders are major health problems, which are often co-existing. Mechanistically, these conditions can be attributed to endothelial dysfunction, a process coupled with reduced nitric oxide (NO) bioavailability. READ MORE

  7. 5. Renal cell death in urinary tract infections : role of E. coli toxins

    Author : Ming Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Pyelonephritis; Escherichia coli toxins; ERK; LPA; cell death; carbon monoxide; hemolysin; nitric oxide; heme oxygenase-1; dexamethasone; kidney development;

    Abstract : Febrile urinary tract infections (UTI) are common bacterial illnesses in children. Several follow up studies have shown that 10-15 % of infants with pyelonephritis will develop permanent renal damage, i.e., renal scars, which in turn may lead to chronic diseases such as hypertension and renal insufficiency. READ MORE