Search for dissertations about: "early detection of breast cancer"

Showing result 1 - 5 of 48 swedish dissertations containing the words early detection of breast cancer.

  2. 1. Type IV collagen in breast and colorectal cancer : a potential biomarker of metastatic disease

    Author : Moa Lindgren; Hanna Nyström; Ingrid Ljuslinder; Malin Sund; Kristian Pietras; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; colorectal liver metastases; breast cancer; breast cancer metastases; tumor marker; biomarker; stroma; type IV collagen;

    Abstract : Background: Metastatic colorectal cancer (mCRC) and metastatic breast cancer (mBC) are two leading causes of cancer-related mortality worldwide. Early detection of metastatic disease is critical, and sensitive, easily accessed and cost-effective biomarkers that can diagnose mBC and mCRC at an early stage would have high clinical value. READ MORE

  4. 2. Molecular Analysis of Breast Cancer Transcriptomes, Genomes, and Circulating Tumor DNA

    Author : Eleonor Olsson; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer stem cells; RNA splicing; breast cancer; mutations; circulating tumor DNA; early detection of recurrent breast cancer; sequencing;

    Abstract : Breast cancer is a very heterogeneous disease in terms of clinical characteristics, genetic aberrations and prognosis. In Paper I, we focused on the CD44 molecule that often is aberrantly expressed in breast cancer and is widely used as a marker for cancer stem cells. READ MORE

  5. 3. Role of mitochondria in early molecular diagnosis and prognosis of cancer

    Author : Yanni Li; Allmänmedicin och klinisk epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; mtDNA copy number; mitochondrial-related nuclear genes; mtDNA mutations; diagnosis; prognosis; biomarker;

    Abstract : Background:Earlier clinical detection of cancer may improve survival as well as offer opportunities for less invasive treatment options. This thesis explores whether the mitochondria and its related genes in the nuclear genome can be used as novel methods for the diagnosis and prognosis of cancers. READ MORE

  6. 4. Someone has to tell them : exploring hereditary cancer risk disclosure in Sweden

    Author : Carolina Hawranek; Anna Rosén; Senada Hajdarevic; Beatrice S. Melin; Barbro Numan Hellquist; Maria Katapodi; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; hereditary cancer; prevention; family disclosure; family communication; cancer worry; risk information; at-risk relatives; cascade testing; genetic counselling; public opinion; Oncology; onkologi; Genetics; genetik;

    Abstract : Summary in EnglishBackground: An awareness of hereditary susceptibility for breast, ovarian and colorectal cancer in high-risk families enables targeted cancer prevention. A discovered hereditary risk in one family member (proband) may thus be important for several members of that family. READ MORE

  7. 5. Nuclease Activity as a Biomarker in Cancer Detection

    Author : Alien Balian; Frank Hernandez; Kajsa Uvdal; Baris Ata Borsa; Ester Boix Borrás; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nucleases; Nuclease activity; Cancer detection; Diagnosis; Oligonucleotides; Nucleic acid probes; MRI-probes; Activatable probes;

    Abstract : Nucleases are a group of enzymes that cleave the phosphodiester bonds in nucleic acids. As such, nucleases act as biological scissors that exhibit a plethora of fundamental roles, in prokaryotes and eukaryotes, dependent or non-dependent on their catalytic capability. READ MORE