Search for dissertations about: "electrospray ionization"

Showing result 1 - 5 of 69 swedish dissertations containing the words electrospray ionization.

  1. 1. Mass Spectrometry with Electrospray Ionization from an Adjustable Gap

    University dissertation from Stockholm : KTH

    Author : Patrik Ek; KTH.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Electrospray ionization; mass spectrometry; nanoelectrospray; ESI; MS; chip; emitter; gap; liquid bridge; nozzle; peptides; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi;

    Abstract : In this thesis the fabrication and analytical evaluation of two new electrospray emitters utilized for mass spectrometry analysis is presented. The emitters are based on a new concept, where the spray orifice can be varied in size. The thesis is based on two papers.All present-day nanoelectrospray emitters have fixed dimensions. READ MORE

  2. 2. New methods for sensitive analysis with nanoelectrospray ionization mass spectrometry

    University dissertation from Stockholm : KTH

    Author : Patrik Ek; KTH.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; electrospray ionization; nanoelectrospray ionization; adjustable gap; emitter; miniaturization; improved sensitivity; nanoliter picoliter sample volumes; Alzheimer’s disease; amyloid-beta Aβ ; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi;

    Abstract : In this thesis, new methods that address some current limitations in nanoelectrospray mass spectrometry (nESI-MS) analysis are presented. One of the major objectives is the potential gain in sensitivity that can be obtained when employing the proposed techniques. READ MORE

  3. 3. Electrospray Ionization Mass Spectrometry for Determination of Noncovalent Interactions in Drug Discovery

    University dissertation from Stockholm : KTH

    Author : Kurt Benkestock; KTH.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; electrospray ionization; drug discovery; noncovalent interaction; complexes; human serum albumin HSA ; fatty acid binding protein FABP ; ribonuclease; ligand screening; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi;

    Abstract : Noncovalent interactions are involved in many biological processes in which biomolecules bind specifically and reversibly to a partner. Often, proteins do not have a biological activity without the presence of a partner, a ligand. READ MORE

  4. 4. Electrophoretic focusing in microchannels combined with mass spectrometry Applications on amyloid beta peptides

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Saara Mikkonen; KTH.; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amyloid beta; computer simulation; electrophoresis; electrospray ionization; isoelectric focusing; isotachophoresis; MALDI; mass spectrometry; microchannel; microchip; nano-electrospray ionization; preconcentration; separation; Kemi; Chemistry;

    Abstract : Analysis of low-abundance components in small samples remains a challenge within bioanalytical chemistry, and new techniques for sample pretreatments followed by sensitive and informative detection are required. In this thesis, procedures for preconcentration and separation of proteins and peptides in open microchannels fabricated on silicon microchips are presented. READ MORE

  5. 5. Aspects of Porous Graphitic Carbon as Packing Material in Capillary Liquid Chromatography

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Törnkvist; Uppsala universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; PGC; porous graphitic carbon; stationary phase; packing material; LC; liquid chromatography; miniaturized; chiral; enantiomer; ESI; electrospray ionization; mass spectrometry; polar compounds; L-DOPA; dopamine; biological samples; biological matrix; Analytisk kemi; PGC; poröst grafitiserat kol; stationärfas; packningsmaterial; LC; vätskekromatografi; miniatyriserade system; kiral; enantiomer; ESI; electrospray jonisation; mass spektrometri; polära föreningar; L-DOPA; dopmamine; biologiska prover; biologisk matris; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi; Analytical Chemistry; Analytisk kemi;

    Abstract : In this thesis, porous graphitic carbon (PGC) has been used as packing material in packed capillary liquid chromatography. The unique chromatographic properties of PGC has been studied in some detail and applied to different analytical challenges using both electrospray ionization-mass spectrometry (ESI-MS) and ultra violet (UV) absorbance detection. READ MORE