Search for dissertations about: "endothelial-to-hematopoietic transition"

Found 3 swedish dissertations containing the words endothelial-to-hematopoietic transition.

  2. 1. Modelling Human Developmental Hematopoiesis. Towards in vitro Generation of Human Hematopoietic Stem Cells

    Author : Carolina Guibentif; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human pluripotent stem cells; Embryonic Development; endothelial-to-hematopoietic transition; Hematopoiesis;

    Abstract : The possibility to manufacture hematopoietic stem cells (HSCs) in the laboratory would provide an indefinite source of cells for patients requiring bone marrow transplantation. Moreover, combined with the progress in gene editing techniques, it would provide a novel platform for gene and cell replacement therapies for a range of currently incurable congenic and acquired disorders. READ MORE

  4. 2. Towards Generation of Human Hematopoietic Stem Cells from Pluripotent Stem Cells

    Author : Roger Rönn; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hematopoietic stem cells; pluripotent stem cells; embryonic development.; in vitro differentiation;

    Abstract : There is a pressing need for compatible Hematopoietic Stem Cells (HSCs), in high quantities and of good clinical quality, to ensure optimal treatment for patients with various blood malignancies. Pluripotent Stem Cells (PSCs) have the potential to be a source for generating HSCs. READ MORE

  5. 3. Mechanisms Underlying the Specification of Definitive Hematopoiesis

    Author : Rita Alves; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GATA2; mitotic bookmarking; HSC; transcription factors; reprogramming;

    Abstract : Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. READ MORE