Search for dissertations about: "endothelin receptor antagonism"

Showing result 1 - 5 of 12 swedish dissertations containing the words endothelin receptor antagonism.

2. 1. Cardiovascular risk factors in renal artery stenosis : Effects of renal angioplasty and angiotensin II receptor antagonism

   Author : Elzbieta Nowakowska-Fortuna; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; renovascular hypertension; endothelin 1; apolipoprtoein C-III; brain natriuretic peptides; angiotensin II receptor antagonism; renal angioplasty; atherosclerotic renal artery stenosis;

   Abstract : Renovascular hypertension (RVH) caused by atherosclerotic renal artery stenosis (ARAS) is one of the most common forms of secondary hypertension. The prognosis for patients with RVH is much worse compared to patients with primary hypertension, and caused by a high cardiovascular morbidity. READ MORE

4. 2. Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock

   Author : Anna Somell; Karolinska Institutet; Karolinska Institutet; []
   Keywords : sepsis; endotoxin; fluid resuscitation; hypertonic saline dextran; endothelin; tezosentan;

   Abstract : Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due to hypoperfusion and inflammatory changes. READ MORE

5. 3. The endothelin system and cardiopulmonary dysfunction in porcine endotoxin shock

   Author : Michael Wanecek; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Endothelin; endothelin receptor antagonism; cyclooxygenase inhibition; endotoxin; sepsis; shock; pulmonary hypertension; cardiac dysfunction;

   Abstract : The endothelium-derived peptide endothelin-1, acting via the endothelinA and endothelinB receptors, possesses strong vasoconstrictive properties shown to affect pulmonary and systemic circulation as well as cardiac function. During septic and endotoxin shock a marked increase in circulating plasma endothelin-1 levels is observed which is associated with morbidity, cardiac dysfunction and lung injury. READ MORE

6. 4. Renal failure in experimental sepsis : role of endothelin and the toll-like receptor 4

   Author : Johan Fenhammar; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Sepsis is the leading cause of renal failure in critically ill patients, but the pathogenesis of septic kidney dysfunction is poorly defined. The current paradigm states that hypoperfusion and excessive renal vasoconstriction results in renal ischemia. READ MORE

7. 5. Endothelin in the pulmonary circulation with special reference to hypoxic pulmonary vasoconstriction

   Author : Peter Holm; Karolinska Institutet; Karolinska Institutet; []
   Keywords : bosentan; BMS-182874; ; BQ-123; BQ-788; endothelin; endothelium; hypoxia; hypoxic pulmonary vasoconstriction; pulmonary hypertension; receptor antagonism; TBC 11251.;

   Abstract : A number of substances originating from the pulmonary endothelium have recently been found to be involved in the regulation of pulmonary vascular tone. Accumulating evidence suggests that endothelial dysfunction contributes to pulmonary hypertension, an important clinical problem often associated with hypoxemia. READ MORE