Search for dissertations about: "endotoxin elimination"

Showing result 1 - 5 of 6 swedish dissertations containing the words endotoxin elimination.

2. 1. Modulating Organ Dysfunction in Experimental Septic Shock : Effects of Aminoglycosides, Antiendotoxin Measures and Endotoxin Tolerance

   Author : Markus Castegren; Jan Sjölin; Claes Frostell; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipopolysaccharide; animal model; pig; tobramycin; endotoxin elimination; immunoparalysis; secondary sepsis; Infectious diseases; Infektionssjukdomar; Infektionssjukdomar; Infectious Diseases;

   Abstract : Sepsis is a common diagnose in the intensive care population, burdened with a high mortality. The systemic inflammatory reaction underlying the development of septic organ dysfunction can be modeled using Gram-negative bacterial lipopolysaccharide, endotoxin. READ MORE

4. 2. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

   Author : Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

   Abstract : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. READ MORE

5. 3. Environmental and immunological factors associated with allergic disease in children

   Author : Sara Tomičić; Malin Fagerås Böttcher; Karin Fälth-Magnusson; Esbjörn Telemo; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allergic diseases; dysregulated immune responses; IgG4; Immunobiology; Immunbiologi;

   Abstract : Background: Allergic diseases are characterised by dysregulated immune responses. The first manifestation of the atopic phenotype is often food allergy, with symptoms like eczema. Food allergy in children is generally outgrown before 3 years of age, but a temporary food elimination diet is often advocated. READ MORE

6. 4. The use of volume kinetics as a method to optimise fluid therapy

   Author : Christer Svensén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: This thesis presents a new application of pharmacokinetic analysis, usually applied to drugs, to the disposition of intravenous fluid. One-volume and two-volume models were developed and non-linear regression was used to characterise the blood marker dilution versus time, relative to the administered dose of intravenous fluid. READ MORE

7. 5. Carbon monoxide in biological systems : An experimental and clinical study

   Author : Anna-Maja Åberg; Jan-Erik Larsson; Dick Delbro; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carbon monoxide; physiological effects; systemic inflammation; analytical method; blood; exhaled air; pharmacokinetics; cigarette smoking; blood donation; cytokines; Anaesthetics; Anestesiologi;

   Abstract : Background: Carbon monoxide (CO) is a toxic gas, but it is also produced endogenously when haem is degraded. When produced in vivo, CO is believed to have positive biological effects. For example it activates the production of cyclic guanosine mono-phosphate and causes vasodilatation. READ MORE