Search for dissertations about: "engraftment"

Showing result 1 - 5 of 79 swedish dissertations containing the word engraftment.

2. 1. Properties of Endothelium and its Importance in Endogenous and Transplanted Islets of Langerhans

   Author : Åsa Johansson; Per-Ola Carlsson; JanOve Sehlin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; islet transplantation; endothelial cells; engraftment; beta cells; Diabetology; Diabetologi; Medical Cell Biology; medicinsk cellbiologi;

   Abstract : Transplantation of insulin producing cells is currently the only cure for type 1 diabetes. However, even though the Edmonton protocol markedly increased the success rate of pancreatic islet transplantation, the long term insulin independence is still very poor. An adequate engraftment is critical for islet graft survival and function. READ MORE

4. 2. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

   Author : Joey Lau; Per-Ola Carlsson; Leif Jansson; Carina Carlsson; Caroline Kampf; Annika Tibell; Uppsala universitet; []
   Keywords : Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

   Abstract : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. READ MORE

5. 3. Mesenchymal stromal/stem cells : expansion, engraftment and immune modulation

   Author : Håkan Samuelsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Due to their production of hematopoietic growth factors and their immunomodulatory capacity, bone marrow-derived mesenchymal stromal/stem cells (MSC), are a promising tool in the procedure of hematopoietic stem cell transplantation (HSCT). Seven patients undergoing allogeneic HSCT were co-infused with MSC. READ MORE

6. 4. Modifying xenogeneic immune recognition and engraftment by genetic engineering

   Author : Zhong He; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Xenotransplantation; gene therapy; gene transfer; endothelium; promoters; monocytes; NK cells; alpha-Gal; lentivirus vectors; pancreatic islets;

   Abstract : Transplantation using xenogenic organs, tissues and cells (i.e. xenotransplantation) is a potential solution to the shortage of those from human sources. Vascular endothelial cells (ECs) are the most immediate barrier between the xenogeneic donor organ and the host defense systems. READ MORE

7. 5. On CNS injury and olfactory ensheathing cell engraftment strategies

   Author : I-Hui Lee; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) is limited because of lack of nerve-growth stimulatory factors and presence of an insurmountable molecular environment for injured axons. This thesis aims to study neural regeneration following adult CNS injury, using rodent models of spinal cord injury, dorsal root avulsion, and Parkinson s disease. READ MORE