Search for dissertations about: "enterohepatic circulation"

Showing result 1 - 5 of 13 swedish dissertations containing the words enterohepatic circulation.

  2. 1. Mechanism-based modeling of biological processes involved in oral absorption

    Author : Benjamin Guiastrennec; Mats O. Karlsson; Martin Bergstrand; Jörg Lippert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; absorption; bile acids; enterohepatic circulation; food effect; gallbladder; in vitro in vivo correlation; NONMEM; pediatrics; pharmacometrics; tuberculosis; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : For orally administered drugs, the rate and extent of absorption are governed by the physiology of the gastrointestinal tract, the characteristics of the dosage form and the physico-chemical properties of the drug. This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach. READ MORE

  4. 2. Piperaquine - Bioanalys, drug metabolism and pharmacokinetics

    Author : Joel Tärning; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Piperaquine; malaria; Plasmodium falciparum; antimalarials; ACT; pharmacokinetics; NONMEM; population pharmacokinetics; NCA; bioavailability; enterohepatic circulation; metabolism; metabolites; animal models; bioanalysis; regression models; validation; HPLC; LC-MS MS; H-NMR; FTICR-MS;

    Abstract : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. READ MORE

  5. 3. Early steps of Eicosanoid precursor absorption and tissue distribution

    Author : Tor Melin; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipids; mebran; steroider; Lipider; steroids; membranes; Gastro-enterology; Gastroenterologi;

    Abstract : Eicosanoids are important for a wide range of physiological and pathophysiological processes.How their essential fatty acid precursors are absorbed and tissue distributed is not well charactherized. When given orally to rats, arachidonic acid (20:4) was retained in the small intestine to a larger extent than linoleic acid (18:2). READ MORE

  6. 4. Functional study of nuclear receptors and bile acids in the modulation of cholesterol homeostasis

    Author : Xiaoli Hu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol carries multiple biological functions in the body, and imbalanced cholesterol metabolism leads to atherosclerosis and cardiovascular diseases. The present thesis aims to extend the knowledge of cholesterol metabolic regulation mediated by nuclear receptor LXRs and bile acids, two major players in the homeostasis of body cholesterol. READ MORE

  7. 5. Amino acid conjugation of fatty acids as a novel pathway in lipid metabolism

    Author : Sarah-Jayne Reilly; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Peroxisomes are cell organelles that play an important role in the metabolism of a variety of lipids including very long chain fatty acids, dicarboxylic acids, bile acids, and xenobiotic carboxylic acids to name a few. To accomplish these tasks peroxisomes contain many proteins involved in lipid metabolism including members of the Type I acyl-CoA thioesterase/acyltransferase protein family. READ MORE