Search for dissertations about: "enzyme kinetics"

Showing result 21 - 25 of 135 swedish dissertations containing the words enzyme kinetics.

  2. 21. Exploring Inhibitors of HIV-1 Protease : Interaction Studies with Applications for Drug Discovery

    Author : Maria T. Lindgren; Helena Danielson; Jozsef Tözser; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; kinetics; biosensors; ADME; drug discovery; SPR; resistance; inhibition; copper; Biokemi; Biochemistry; Biokemi;

    Abstract : A variety of HIV-1 protease inhibitors and their interactions with the enzyme have been characterized in order to identify novel and improved drugs against AIDS. The investigated inhibitors were represented by clinical and non-clinical inhibitors, active site and allosteric inhibitors, transition-state analogues and metal-ions. READ MORE

  4. 22. Metabolism of quinoline 3-carboxamide compounds, a group of synthetic immunomodulators, in various species

    Author : Helen Tuvesson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymologi; Proteiner; enzymology; Proteins; Gastroenterologi; Gastro-enterology; pharmacokinetics; enzyme kinetics; quinoline 3-carboxamides; Keywords: Metabolism; cytochrome P450;

    Abstract : Cytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. READ MORE

  5. 23. Structure-Function Studies of Enzymes from Ribose Metabolism

    Author : C. Evalena Andersson; Sherry Mowbray; Phil Evans; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; activation; isomerase; kinase; potassium; product inhibition; ribose; ribose 5-phosphate; x-ray crystallography; enzyme kinetics; fluorescence spectroscopy; protein structure; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : In the pentose phosphate pathway, carbohydrates such as glucose and ribose are degraded with production of reductive power and energy. Another important function is to produce essential pentoses, such as ribose 5-phosphate, which later can be used in biosynthesis of nucleic acids and cofactors. READ MORE

  6. 24. Modulators of Saccharomyces cerevisiae cytochrome c oxidase : Implications for the regulation of mitochondrial respiration

    Author : Camilla Rydström Lundin; Peter Brzezinski; Christoph von Ballmoos; Shelagh Ferguson-Miller; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; cytochrome c; OXPHOS; membrane protein; kinetics; ligand-binding; electron transfer; Rcf1; respiratory supercomplexes; Saccharomyces cerevisiae; Biochemistry; biokemi;

    Abstract : Oxidative phosphorylation in mitochondria is performed by enzyme complexes and electron carriers that reside in the inner membrane. It is now generally accepted that these respiratory enzyme complexes assemble into larger so-called supercomplexes. However, it is presently not known why, under which conditions or how these supercomplexes form. READ MORE

  7. 25. Computational Protein Evolution : Modeling the Selectivity and Promiscuity of Engineered Enzymes

    Author : Klaudia Szeler; Shina C. Lynn Kamerlin; Mikael Widersten; Maria Ramos; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzymes; kinetics; catalysis; density functional theory; empirical valence bond; diesters; evolution; promiscuity; Biokemi; Biochemistry;

    Abstract : Enzymes are biological catalysts that significantly increase the rate of all biochemical reactions that take place within cells and are essential to maintain life. Many questions regarding their function remain unknown. READ MORE