Search for dissertations about: "epithelial-mesenchymal interaction"

Showing result 1 - 5 of 7 swedish dissertations containing the words epithelial-mesenchymal interaction.

  2. 1. A functional genomics approach to PDGF and pericyte biology

    Author : Cecilia Bondjers; Göteborgs universitet; []
    Keywords : PDGF; hair follicle; skin; testis; epithelial-mesenchymal interaction; microarray; pericyte; transgenic mouse;

    Abstract : The rapid expansion of genome sequence data demands for increased efforts and speed concerning functional analysis of gene products. Two approaches to such analysis, namely transgenic technologies and analysis of gene expression have successfully been used to study functions of gene products in complex organisms, such as mammals. READ MORE

  4. 2. Functions of PDGF-A and -C. Essential ligands for the PDGF alpha receptor

    Author : Hans Boström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelet-derived growth factor; PDGF-A; PDGF-C; PDGF alpha receptor; extracellular retention; gene targeting; mouse development; epithelial-mesenchymal interaction; lung; alveolar formation; spina bifida; gastrointestinal villus;

    Abstract : Altered protein kinase activity is a contributing factor in many diseases including most formsof human malignancies, and there is reason to believe that protein kinases will prove to be majordrug targets in the treatment of cancer. Protein kinases mediate most of the signal transduction ineukaryotic cells, regulating cellular events such as transcription, metabolism, proliferation,cytoskeletal rearrangement, migration, differentiation and apoptosis. READ MORE

  5. 3. The role of hyaluronan and its CD44 receptor in inflammation and cancer

    Author : Chun-Yu Lin; Jyrki Tenhunen; Miklós Lipcsey; Paraskevi Heldin; Markku Tammi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD44; Dengue; Hyaluronan; HAS2; iASPP; TGFbeta; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Hyaluronan, an important extra-cellular matrix molecule, was thought to be interstitial connecting glue decades ago. However, recent evidence has revealed that hyaluronan and its binding proteins also play crucial roles in various pathophysiological conditions in humans, including inflammation and infection. READ MORE

  6. 4. Exploring immunotherapeutic targets in the tumor microenvironment

    Author : Anna-Maria Georgoudaki; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The immune system has developed along with the evolution of increasingly complex cellular organisms to sustain homeostasis and protect from threats. Cancer, a detrimental side effect of increasing organismic complexity, typically sequesters the immune system and hijacks its functions for its own prosperity. READ MORE

  7. 5. Immunoregulatory properties of CD137-CD137 ligand axis in tumours and chronic inflammatory conditions

    Author : Luu Nguyen Khang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : CD137 (4-1BB/TNFRSF9) is a member of the TNF receptor superfamily. CD137 expression is activation-dependent, and usually reported on T cells and NK cells. Its natural ligand is CD137 ligand (CD137L), mainly found on antigen-presenting cells (APC) such as monocytes, or dendritic cells. READ MORE