Search for dissertations about: "escitalopram"

Showing result 1 - 5 of 20 swedish dissertations containing the word escitalopram.

  2. 1. PET studies of the serotonin transporter in the human brain

    Author : Johan Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : positron emission tomography; MADAM; WAY 100635; 5-HTT; 5-HT1A receptors; receptor occupancy; major depressive disorder; citalopram; escitalopram;

    Abstract : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. READ MORE

  4. 2. Influence of serotonin on anxiety-like behavior in rat

    Author : Robert Pettersson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anxiety; Serotonin; SSRI;

    Abstract : It is well-established that serotonin is involved in the regulation of mood and behaviour, partly implied by the therapeutic effect of prolonged treatment with selective serotonin reuptake inhibitors (SSRI) on mood and anxiety disorders. However, the mechanisms behind the paradoxical exacerbation of anxiety described during initial treatment, as well as behind the therapeutic effects of prolonged treatment with SSRIs, remain poorly understood. READ MORE

  5. 3. On antidepressant effects of running and SSRI : focus on hippocampus and striatal dopamine pathways

    Author : Astrid Bjørnebekk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Depression; exercise; neuropeptides; cell proliferation; neurogenesis; NPY; BDNF; Flinders Sensitive Line;

    Abstract : Considering the heterogeneous character of depression, it seems likely that many brain regions are involved mediating the diverse symptoms of depression. For example, the mesolimbic DA system has a central function for motivational behaviors and pleasure seeking, and it is possible that malfunctioning of brain reward systems could be an underlying mechanism of the anhedonia experienced in depressive illness. READ MORE

  6. 4. PET studies on the mechanism of monoaminergic drugs

    Author : Magdalena Nord; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Positron emission tomography (PET) is a molecular imaging technique that allows for examinations of neurochemistry directly in the living human brain. In the present thesis, PET was used to assess the pharmacological effects of two drugs representing the major classes of antipsychotic and antidepressant drugs. READ MORE

  7. 5. CYP2C19 polymorphisms in drug metabolism and response

    Author : Ming Chang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. READ MORE