Search for dissertations about: "estrogen receptor alpha"

Showing result 11 - 15 of 61 swedish dissertations containing the words estrogen receptor alpha.

  2. 11. Theoretical Studies of Anti-cancer Drug Tamoxifen and Estrogen Receptor Alpha

    Author : Gao Li; Yaoquan Tu; Lennart Nilsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : For decades tamoxifen (TAM) has been widely used for treatment of breast cancer by mediating mainly the estrogen receptor α (ERα) signaling pathways, whereby it suppresses estrogen stimulated cancer cell growth. The clinical response of TAM has been linked to cytochrome P450 2D6 (CYP2D6), which is the main isoform responsible for the conversion of TAM to the active metabolites 4-hydroxyTAM (OHT) and endoxifen. READ MORE

  4. 12. Prevention of beta-cell dysfunction via targeting novel GPCRs in pancreatic islets

    Author : Rajesh Kumar; Islet cell physiology; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type II Diabetes; GPCR; Pancreatic islets; Estrogen; Alpha-1 antitrypsin.;

    Abstract : The primary aim of this thesis was to investigate the role of G protein coupled receptors (GPCRs) in insulin secretion and beta-cell survival. The second aim was to determine which pathway is involved in insulin release and beta-cell protection via GPCRs. READ MORE

  5. 13. Exploring the genome-wide impact of estrogen receptor alpha and estrogen receptor beta in breast and colon cancer cells

    Author : Karin Edvardsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogen signaling is involved in the development and progression of breast cancer and is implicated to be protective in colon cancer. Estrogenic actions are conveyed through transcriptional regulation by ligand stimulated estrogen receptors (ERα and ERβ). READ MORE

  6. 14. Signal transduction via estrogen receptors (ERs) and estrogen receptor-related receptors (ERRs)

    Author : Katarina Pettersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogens influence post-natal development and function of the female reproductive system and other organs including bone and cardiovascular system. Estrogens are also involved in the development and growth of certain cancers in e.g. breast and uterine endometrium. READ MORE

  7. 15. Estrogen signaling in stroke : genetic and experimental studies

    Author : Magnus Strand; Tommy Olsson; Jan Hillert; Umeå universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; intracerebral hemorrhage; ischemic stroke; genetics; ERα; OPG; 17β-estradiol; enriched environment; learning and memory; hippocampus; NGFI-A; Medicine; Medicin;

    Abstract : Stroke is a common and multifactorial disease influenced by genetic and environmental risk factors. It is a highly heterogeneous entity consisting of two main types, ischemic (80%) and hemorrhagic (20%) stroke. The most common form of hemorrhagic stroke is intracerebral hemorrhage (ICH). READ MORE