Search for dissertations about: "estrogen receptor modulators"

Showing result 1 - 5 of 13 swedish dissertations containing the words estrogen receptor modulators.

  2. 1. Immune regulation by selective estrogen receptor modulators

    Author : Angelina I Bernardi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Endocrinology; Mice; Lasofoxifene; Bazedoxifene; Raloxifene; Estrogen; Osteoporosis; B cells; T cells; Rheumatoid arthritis;

    Abstract : At menopause, the levels of estrogen decline, leading to loss of estrogen-mediated protective effects on bone and an increased risk of osteoporosis. Hormone replacement therapy, containing estrogen, has been used for many years to prevent and treat osteoporosis in postmenopausal women. READ MORE

  4. 2. Arthritis and immune-mediated bone loss - role of estrogen signalling pathways

    Author : Cecilia Engdahl; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Arthritis; Bone; Estrogen;

    Abstract : Objective: Rheumatoid arthritis (RA) is associated with immune-mediated bone loss and thereby increased risk for fractures. Estrogen and selective estrogen receptor modulators (SERMs) ameliorate not only the incidence and progression of experimental RA but also the immune-mediated bone loss. READ MORE

  5. 3. Effect of selective estrogen receptor modulators (SERMs) on growth plate cartilage

    Author : Elham Karimian; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : More than 300 years ago Dr. Stephen Hales drilled holes in the shaft of chicken bones and noted that as the animal grew, the distance between these holes remained constant. This led him to conclude that longitudinal bone growth occurs at the end of the long bones, rather than in the middle. READ MORE

  6. 4. The relative importance of sex steroid receptors for bone metabolism

    Author : Sofia Movérare-Skrtic; Göteborgs universitet; []
    Keywords : bone; estrogen; androgen; transgenic; microarray;

    Abstract : Estrogen deficiency increases the risk of a wide variety of pathological conditions including osteoporosis. Morbidity from osteoporosis is substantial in both men and women. READ MORE

  7. 5. Effect of estrogen on longitudinal bone growth

    Author : Andrei S Chagin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Growth plate; chondrocytes; estrogen receptors; androgen; tamoxifen.;

    Abstract : Longitudinal bone growth occurs at the growth plate, a thin layer of cartilage between the epiphysis and the metaphysis of long bones. In the growth plate resting chondrocytes proliferate, differentiate into a hypertrophic form, and finally become terminal hypertrophic chondrocytes before giving rise to bone. READ MORE