Search for dissertations about: "experimental cancer"

Showing result 1 - 5 of 376 swedish dissertations containing the words experimental cancer.

  2. 1. The proteasome as a target for cancer therapy

    Author : Peter Larsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Cell viability assay; Chemotherapy; Drug repurposing; Genomic and transcriptomic signatures; Prognostic biomarkers; Proteasome; Proteasome genes; Proteasome inhibitors; Drug sensitivity biomarkers; Synergistic effect; Triple-negative breast cancer;

    Abstract : The main objective of this PhD thesis was to evaluate the significance of proteasome genes as prognostic markers for different cancer types and identify specific cancer forms that respond to proteasome inhibition. The proteasome (PSM) plays an important role in maintaining cellular proteostasis and degrades the majority of proteins that require breakdown in the cell. READ MORE

  4. 2. Obesity, Adipocytes and Breast Cancer – Insights from Translational Studies

    Author : Malin Bergqvist; Bröstcancer - prevention & intervention; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Breast cancer risk; Breast cancer prognosis; Obesity; Adipocyte; Adipokines; CAP; Neutrophil to lymphocyte ratio;

    Abstract : Background: Being overweight is becoming the new normal, and more than half of the adult Swedish population is overweight which poses a risk to public health. Overweight and obese women have both an increased risk and a worse prognosis for breast cancer, compared with women of normal weight. READ MORE

  5. 3. Carbonate Ions and Gastric Cancer

    Author : Roy Ehrnström; Malmö Patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; ODC; COX-2; inflammation; Wistar rats; duodenogastric reflux; Medicin människa och djur ; proliferation; gastrojejunostomy; carbonate ions; Experimental gastric cancer;

    Abstract : Nearly one million new cases of gastric cancer are diagnosed annually throughout the world. Even though the incidence has fallen dramatically in recent decades, this disease is still the second leading cause of cancer death in a global perspective. READ MORE

  6. 4. Pancreatic Cancer. Experimental and Clinical Studies

    Author : David Ljungman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic neoplasms; Proteasome inhibitors; Apoptosis; Intracellular signaling peptides and proteins; Epidermal growth factor receptor; Pancreaticoduodenectomy; Cost and cost analysis; Quality-adjusted life years; Copy number variations; Comparative genomic hybridization;

    Abstract : Background: Pancreatic cancer is one of the most lethal of known cancers and the only treatment with possibility of cure is surgery. The costs associated with treatment of pancreatic cancer are reputably high, both in terms of morbidity and financially. READ MORE

  7. 5. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study

    Author : Magdalena Cwikiel; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; cell culture.; scanning and transmission electron microscopy; endothelium; lipid peroxidation; free radical; fibrinogen; 5-fluorouracil; blood and plasma viscosity; cardiotoxicity; cancerology; Cytologi; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). READ MORE