Search for dissertations about: "exploring molecular interactions"

Showing result 1 - 5 of 48 swedish dissertations containing the words exploring molecular interactions.

2. 1. Exploring Molecular Interactions : Synthesis and Studies of Clip-Shaped Molecular Hosts

   Author : Anjaneya Prasad Polavarapu; Helena Grennberg; Adolf Gogoll; Jerker Mårtensson; Uppsala universitet; []
   Keywords : Organic chemistry; Glycoluril clips; host-guest systems; supramolecular chemistry; complexation induced shifts; conformational restriction; NMR spectroscopy; fullerene binding; Organisk kemi;

   Abstract : Molecular recognition via noncovalent interactions plays a key role in many biological processes such as antigen-antibody interactions, protein folding, the bonding and catalytic transformation of substrates by enzymes, etc. Amongst these noncovalent interactions, electrostatic interactions, hydrogen bonding, π-π interactions, and metal-to-ligand bonding are the most prominent. READ MORE

4. 2. Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

   Author : Ida E. Andersson; Jan Kihlberg; Anna Linusson Jonsson; Craig Crews; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; class II MHC; T-cell receptor; rheumatoid arthritis; collagen-induced arthritis; glycopeptide; amide bond isostere; comparative modeling; rational design; molecular docking; molecular dynamics simulation; statistical molecular design; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry; Biorganic Chemistry; bioorganisk kemi; datorlingvistik; computational linguistics;

   Abstract : Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). READ MORE

5. 3. Exploring molecular interactions between polypeptide conjugates and protein targets : Manipulating affinity by chemical modifications

   Author : Aleksandra Balliu; Lars Baltzer; Oliver Seitz; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polypeptide conjugates; protein targets; molecular recognition; affinity enhancement; conjugation;

   Abstract : In this thesis molecular interactions between polypeptide conjugates and protein targets were investigated. Polypeptides were derivatized with small organic molecules, peptides and oligonucleotides. New strategies were developed with the aim to increase affinities for proteins of biological interest. READ MORE

6. 4. Exploring the Molecular Behavior of Carbohydrates by NMR Spectroscopy : Shapes, motions and interactions

   Author : Olof Engström; Göran Widmalm; Anthony S. Serianni; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; NMR relaxation; DNMR; CORCEMA-ST; carbohydrates; caffeine; O-antigen; glycofullerenes; organisk kemi; Organic Chemistry;

   Abstract : Carbohydrates are essential biomolecules that decorate cell membranes and proteins in organisms. They are important both as structural elements and as identification markers. Many biological and pathogenic processes rely on the identification of carbohydrates by proteins, thereby making them attractive as molecular blueprints for drugs. READ MORE

7. 5. Exploring Selectivity and Hysteresis : Kinetic Studies on a Potato Epoxide Hydrolase

   Author : Diana Lindberg; Mikael Widersten; Gunnar Johansson; Richard N. Armstrong; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Epoxide hydrolase; regioselectivity; selectivity; hysteresis; conformational changes; cooperativity; deep eutectic solvents; methylstyrene oxide; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Abstract : The kinetic mechanism of an α/β hydrolase fold epoxide hydrolase from potato, StEH1, has been studied with the aims of explaining the underlying causes for enantio- and regioselectivity, both being important for product purity. Further effort has been laid upon understanding the causes of a hysteretic behavior discovered in the measurements leading to Paper I. READ MORE