Search for dissertations about: "exposure in-vivo"

Showing result 1 - 5 of 410 swedish dissertations containing the words exposure in-vivo.

2. 1. Engineered nanomaterials in in vivo and in vitro models

   Author : Laura Abariute; NanoLund: Centre for Nanoscience; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; III-V semiconductor nanowires; Nanoparticle exposure; Mouse exposure; Cell exposure; Nanotoxicology; Nanosafety; Fysicumarkivet A:2018:Abariute;

   Abstract : Nanotechnology and engineered nanomaterials (ENM) empower existing technologies. One of the great examples are III-V semiconductor nanowires (NW), which have a broad application range. The occupational safety and hazard organizations draw attention to ENM, as their physical and chemical characteristics differ from the ones of bulk materials. READ MORE

4. 2. Improved basis for cancer risk assessment of acrylamide from food : Determination of glycidamide in vivo doses

   Author : Anna Vikström; Margareta Törnqvist; Kirsi Vähäkangas; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; Miljökemi; miljökemi; Environmental Chemistry;

   Abstract : Acrylamide is formed in heat processing of many common foods. According to animal cancer tests acrylamide is a carcinogen. To estimate the cancer risk from exposure via food, the response at high doses in the cancer tests with rats has to be extrapolated to the exposure levels in humans. READ MORE

5. 3. β-N-methylamino-L-alanine (BMAA)-induced neurotoxicity : Studies in vitro and in vivo

   Author : Lisa Ersson; Malin Andersson; Eva B Brittebo; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BMAA; neurotoxin; neurodegeneration; cellular transport; metabolic profiling; protein-association; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : β-N-methylamino-L-alanine (BMAA) is a neurotoxic non-proteinogenic amino acid produced naturally by cyanobacteria, diatoms and dinoflagellates and it has been detected in samples from fresh and marine water from all over the world. It can bioaccumulate in fish and shellfish, and has a potential to biomagnify in a terrestrial food chain. READ MORE

6. 4. Development of Methods for Assessing Unbound Drug Exposure in the Brain : In vivo, in vitro and in silico

   Author : Markus Fridén; Margareta Hammarlund-Udenaes; Ulf Bredberg; Yuichi Sugiyama; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Drug transport; Tissue distribution; Transporters; Pharmacokinetics; Other pharmacy; Övrig farmaci; Biopharmacy; Biofarmaci; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Abstract : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. READ MORE

7. 5. Short and long-term effects of exposure to low dose and low dose rate of gamma radiation : using in vitro and in vivo models

   Author : Traimate Sangsuwan; Siamak Haghdoost; Eva Forssell-Aronsson; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Low dose; Low dose rate; High dose rate; Ionizing radiation; Adaptive response; Senescence; Premature senescence; Oxidative stress; Drosophila embryo; Mutation; DNA repair; molekylär biovetenskap; Molecular Bioscience;

   Abstract : Assessment of human health risks from exposure to ionizing radiation (IR) is mainly based on the extrapolation of results from epidemiological studies on populations exposed to relatively high doses and often at high dose rates (HDR). Risk estimates after exposure to low doses and in particular at low dose rates (LDR) remain controversial due to a lack of epidemiological evidence. READ MORE