Search for dissertations about: "expression vector"

Showing result 1 - 5 of 136 swedish dissertations containing the words expression vector.

2. 1. Adenovirus vector systems permitting regulated protein expression and their use for in vivo splicing studies

   Author : Magnus Molin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Adenovirus; vector; inducible; gene expression; ASF SF2; splicing; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

   Abstract : We have constructed two adenovirus-based gene expression vector systems permitting regulated protein expression. They are based on the tetracycline-regulated Tet-ON- and the progesterone antagonist RU 486-regulated gene expression systems, which were rescued into E1-deficient adenovirus vectors. READ MORE

4. 2. Expression and processing of cecropin and attacin using a baculovirus vector

   Author : Marianne Hellers; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; mikrobiologi; Microbiology;

   Abstract : The cecropins and attacins are two antibacterial peptides induced uponimmunization in the moth Hyalophora cecropia. They are both synthesized aspreproproteins that are processed and post-translationally modified along the exportpathway. READ MORE

5. 3. Replication-competent adenovirus 11p vector as a new oncolytic agent

   Author : Jim Silver; Ya-Fang Mei; Gunnel Halldén; Umeå universitet; []
   Keywords : Virologi; Adenovirus; Vector; mikrobiologi; Microbiology;

   Abstract : Human adenoviruses (Ads) as vectors have been studied for cancer gene therapy for several decades due to their ability to shut down host cell replication and lyse tumour cells. Ad5 of species C is commonly used as a replication-defective or a replication-competent vector. READ MORE

6. 4. Propionibacterium acnes and its phages

   Author : Rolf Lood; Infektionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Propionibacterium acnes; biofilm; bacteriophage; Siphovirus; pseudolysogeny; heme oxygenase; free radicals; recombinant protein expression; vector;

   Abstract : Microorganisms are everywhere! They can tolerate many diverse extreme environments, such as the human body. Even though many of us might associate the word microorganism with infections and disease, most are actually either harmless or even beneficial for us. READ MORE

7. 5. Development of Gene Therapy for Hematopoietic Stem Cells using Lentiviral Vectors

   Author : Niels-Bjarne Woods; Andreas Ooka; Stefan Karlsson; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cell; Hematopoietic stem cell; lentiviral vector; transduction efficiency; transgene expression; multiple vector copy integration; insertional mutagenesis; NOD SCID mouse; cytogenetics; Genetics; extracellulära vätskor; extracellular fluids; cytogenetik; Genetik; Haematology; Hematologi; Lentivirus : genetics; Human; Genetic Vectors; Hematopoietic Stem Cells : metabolism; Animal; Gene Therapy; Leukemia : therapy; Leukemia : metabolism;

   Abstract : Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation in immune compromised mice. READ MORE