Search for dissertations about: "extracellular DOC"

Found 5 swedish dissertations containing the words extracellular DOC.

2. 1. Microphysiometry in the evaluation of cytotoxic drugs with special emphasis on the novel cyanoguanidine CHS 828

   Author : Sara Ekelund; Sigurd Vitols; Uppsala universitet; []
   Keywords : Medical sciences; Cytotoxic drug development; Cytosensor microphysiometer; cellular metabolism; CHS 828; guanidino-containing compound; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

   Abstract : This thesis describes the use of a new technology, the Cytosensor® microphysiometer, in the in vitro evaluation of cytotoxic drugs, using the lymphoma cell line U-937 GTB and primary cultures of tumour cells from patients as model systems. The method was specifically applied to study the metabolic effects of the novel cyanoguanidine N-(6-(4-chlorophenoxy)hexyl)-N’-cyano-N’’-4-pyridylguanidine, CHS 828, currently in phase I/II clinical trials. READ MORE

4. 2. Organic carbon dynamics in the Baltic Sea : A modelling perspective

   Author : Filippa Fransner; Jonas Nycander; Christoph Humborg; Andreas Oschlies; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; carbon cycle; organic carbon; primary production; remineralisation; terrestrial DOC; extracellular DOC; flexible stoichiometry; Redfield ratio; air-sea CO2 exchange; pCO2; coupled 3D physical-biogeochemical modelling; Gulf of Bothnia; Baltic Sea; atmosfärvetenskap och oceanografi; Atmospheric Sciences and Oceanography;

   Abstract : Coastal seas constitute a link between land and the open ocean, and therefore play an important role in the global carbon cycle. Large amounts of carbon, of both terrestrial and marine origin, transit and are transformed in these waters, which belong to the more productive areas of the oceans. READ MORE

5. 3. Interactions between Bacteria and Fungi on Aquatic Detritus – Causes and Consequences

   Author : Cecilia Mille-Lindblom; Lars Tranvik; Helmut Fischer; Eric Chauvet; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ecology; bacteria; fungi; decomposition; antagonism; extracellular enzymes; competition; macrophytes; dissolved organic carbon DOC ; ergosterol; Ekologi; Terrestrial; freshwater and marine ecology; Terrestisk; limnisk och marin ekologi;

   Abstract : Bacteria and fungi dominate the decomposition of aquatic plants, a major process in the carbon and nutrient cycling in many aquatic systems. Although phylogenetically distant, bacteria and fungi often live in close proximity with each other. Since these microorganisms also have similar ecological functions, interactions have developed between them. READ MORE

6. 4. Utilization of terrestrially derived dissolved organic nitrogen by aquatic bacteria

   Author : Ramunas Stepanauskas; Biologiska institutionen; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; amino acids; spring flood; UV radiation; estuarine mixing; microbial loop; bacterial bioassays; marine eutrophication; bioavailability; Dissolved organic nitrogen; DON; extracellular aminopeptidase; Baltic Sea; Hydrobiology; marine biology; aquatic ecology; limnology; Marinbiologi; limnologi; akvatisk ekologi;

   Abstract : I investigated the bacterial utilization of terrestrially derived dissolved organic nitrogen (DON) in aquatic ecosystems, and assessed the potential role of river-born DON in marine eutrophication. To determine the bioavailability of DON, I developed a bioassay employing N-limited bacterial regrowth cultures, which were calibrated with additions of inorganic nitrogen. READ MORE

7. 5. Chemical, pharmacokinetic and biological aspects of platinum-based drugs

   Author : Jeffrey R Yachnin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The use of cisplatin for the treatment of metastatic testicular cancer is a medical historical landmark given that, for the first time, patients could be cured with drug therapy. A third generation platinum-based drug, oxaliplatin, has been registered for use in the treatment of colorectal cancer. READ MORE