Search for dissertations about: "extracellular"

Showing result 1 - 5 of 1183 swedish dissertations containing the word extracellular.

  1. 1. The release of histone proteins from cells via extracellular vesicles

    University dissertation from Umeå : Umeå University

    Author : Uma Muthukrishnan; Umeå universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone; extracellular vesicles; exosomes; extracellular histones extracellular DNA; cellular stress; proteomics; ESCRT complex; Lrrn1; mid-hindbrain organizer; ovarian cancer; ascites;

    Abstract : Histones are chromatin-associated proteins localized to the nucleus. However, extracellular histones are present in biofluids from healthy individuals and become elevated under disease conditions, such as neurodegeneration and cancer. READ MORE

  2. 2. Pancreatic extracellular communication. Applications to beta cell cultures and islet amyloid polypeptide aggregation

    University dissertation from Chalmers University of Technology

    Author : Diana Ribeiro; Chalmers tekniska högskola.; Chalmers University of Technology.; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular matrix; glucose-stimulated insulin secretion; extracellular vesicles; stem cell differentiation; adipose-derived stem cells; protein aggregation; type 2 diabetes mellitus; islet amyloid polypeptide; 3D-culture; in vitro pancreatic models; insulin; Diabetes mellitus; induced pluripotent stem cells;

    Abstract : Diabetes mellitus (DM) is a disease with epidemic proportions due to increased incidences worldwide, persistence of undiagnosed cases, uncontrolled forms of the disease, association with cardiovascular complications, and lack of definitive treatment options. In particular, type 2 DM (T2DM) is placing an enormous financial burden on worldwide healthcare systems that will increase in the futureThere is a need to develop physiological assay platforms that provide functionally relevant models of diabetes in order to accelerate the discovery of new treatments. READ MORE

  3. 3. Extracellular Matrix Based Materials for Tissue Engineering

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Cecilia Aulin; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Extracellular matrix; collagen synthesis; bioreactor; cell culture; bone morphogenetic protein-2; noggin; hyaluronan; cartilage; MEDICINE Physiology and pharmacology Physiology Medical technology; MEDICIN Fysiologi och farmakologi Fysiologi Medicinsk teknik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Molecular biology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Molekylärbiologi; MEDICINE Surgery Surgical research Orthopaedics; MEDICIN Kirurgi Kirurgisk forskning Ortopedi; MEDICINE Surgery Surgical research Transplantation surgery; MEDICIN Kirurgi Kirurgisk forskning Transplantationskirurgi; MEDICINE Morphology; cell biology; pathology Morphology Biomaterials; MEDICIN Morfologi; cellbiologi; patologi Morfologi Biomaterial; MEDICINE Morphology; cell biology; pathology; MEDICIN Morfologi; cellbiologi; patologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; NATURAL SCIENCES Chemistry Organic chemistry Polymer chemistry; NATURVETENSKAP Kemi Organisk kemi Polymerkemi; TECHNOLOGY Chemical engineering Chemical process and manufacturing engineering Materials chemistry; TEKNIKVETENSKAP Kemiteknik Kemisk process- och produktionsteknik Materialkemi; cellforskning; Cell Research; materialvetenskap; Materials Science; medicinsk cellbiologi; Medical Cell Biology; ortopedi; Orthopaedics;

    Abstract : The extracellular matrix is (ECM) is a network of large, structural proteins and polysaccharides, important for cellular behavior, tissue development and maintenance. Present thesis describes work exploring ECM as scaffolds for tissue engineering by manipulating cells cultured in vitro or by influencing ECM expression in vivo. READ MORE

  4. 4. About hyaluronan in the hypertrophic heart studies on coordinated regulation of extracellular matrix signalling

    University dissertation from Umeå : Umeå universitet

    Author : Urban Hellman; Umeå universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. READ MORE

  5. 5. Cellular responses to amyloid-beta protofibrils Focus on astrocytes, extracellular vesicles and antibody treatment

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Elisabeth Nikitidou; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Amyloid-beta; Protofibrils; Astrocytes; Extracellular vesicles; Antibody; Neurons; Degradation; Medicinsk vetenskap; Medical Science;

    Abstract : Knowledge about the cellular mechanisms behind the initiation and propagation of Alzheimer’s disease (AD) is limited. Decades of research have focused on neuronal abnormalities in AD, but recently more attention has been given to the glial cells. READ MORE