Search for dissertations about: "extrinsic Signaling molecules"

Showing result 1 - 5 of 7 swedish dissertations containing the words extrinsic Signaling molecules.

  2. 1. Defining Regulators of Human Hematopoietic Stem Cells

    Author : Christine Karlsson; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-throughput screening; Expansion; Hematopoietic stem cell; Cord blood; RNA interference; extrinsic Signaling molecules;

    Abstract : Bone marrow transplantation (BMT) is a conceptual and elegant example of stem cell therapy, rendered possible by the dual capacity of hematopoietic stem cells (HSCs) to self-renew and differentiate. These defining features ultimately ensure the production of all blood cell lineages and simultaneous maintenance of the stem cell pool, thereby maintaining lifelong homeostasis. READ MORE

  4. 2. Intrinsic and extrinsic mechanisms for B-cell lymphoma development and progression studied by global gene expression profiling

    Author : Gustav Arvidsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mantle cell lymphoma (MCL) is a rare hematopoietic malignancy characterized by frequent relapses and poor survival, partly due to minimal residual disease, whereby a subset of malignant cells, harbored in protective niches, survive treatment. In vitro and ex vivo experiments have shown that MCL cells can be rescued from apoptosis through interactions with non- malignant cells such as stromal cells. READ MORE

  5. 3. Interleukin 15 throughout murine natural killer cell biology

    Author : Thuy Thanh Luu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells are innate immune cells that mount responses against virally infected, transformed and allogeneic transplanted cells. Equipped with cytolytic molecules and death receptors, NK cells mediate cytotoxicity against cells expressing low levels of MHC class I (MHC-I) or high levels of stress-induced molecules. READ MORE

  6. 4. Bone marrow mesenchymal stem and progenitor cells in myeloid malignancies

    Author : Pingnan Xiao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hematopoietic stem cells (HSCs) reside in bone marrow (BM) microenvironment / niche to self-renew and generate all types of mature blood cells in postnatal life. This process is called hematopoiesis. Normal hematopoiesis is tightly regulated by both intrinsic signaling in HSCs and extrinsic signals from BM niche. READ MORE

  7. 5. Resolving developing neuronal lineages in the ventral midbrain

    Author : Nigel Kee; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The numerous cells and cell types of our bodies originate from a fertilised egg. Through the study of the developing embryo, we have come to understand much about how different cells in different tissues arise from this single cell, and how they are related to one another within an expansive family tree. READ MORE