Search for dissertations about: "familial malignant melanoma"
Showing result 1 - 5 of 8 swedish dissertations containing the words familial malignant melanoma.
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1. Genetic characterization of malignant melanoma and breast cancer
Abstract : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. READ MORE
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2. Molecular genetics of cutaneous malignant melanoma
Abstract : Cutaneous malignant melanoma is an aggressive tumor of melanocytes in the skin with rapidly increasing incidence. Patients with advanced disease have a poor prognosis since the tumor is usually resistant to current therapies. Therefore, the development of novel strategies for preventing and treating melanoma is important. READ MORE
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3. Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations
Abstract : The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. READ MORE
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4. Cancer risks and prognosis in familial melanoma kindreds
Abstract : Malignant melanoma of the skin is one of the most rapidly increasing cancers in many western countries, including Sweden. This incidence rise is mainly attributed to sun-seeking habits with increased intermittent UVR exposure, a major risk factor for melanoma. READ MORE
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5. Cutaneous malignant melanoma aspects of prognostic factors and time : trends in a Swedish population
Abstract : One of the aims of this thesis was to assess the possible impact of primary and secondary preventive activities in the population of Stockholm-Gotland with the objective to reduce the incidence and mortality from cutaneous melanoma. Another aim was to investigate whether thin melanomas and hereditary melanomas represent separate biologic entities. READ MORE