Search for dissertations about: "ferrochelatase"

Showing result 1 - 5 of 12 swedish dissertations containing the word ferrochelatase.

2. 1. Crystallographic studies on porphyrin metallation by ferrochelatase

   Author : David Lecerof; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; thermal and mechanical properties; Condensed matter:stucture; fasjämvikt; kristallografi; egenskaper termiska och mekaniska ; Kondenserade materiens egenskaper:struktur; crystallography; phase equilibria; Magnesium; pi-helix; Zinc; ferrochelatase; Metal binding; porphyrin metallation;

   Abstract : Ferrochelatase catalyses the terminal step in heme biosynthesis by inserting a ferrous ion into protoporphyrin IX. The reaction mechanism has in this thesis been studied by mainly crystallographic methods. READ MORE

4. 2. Ferrochelatase and Magnesiumchelatase: Metal chelation studied with mutants

   Author : Ulf Olsson; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; chlorophyll; heme; barley; mutants; Magnesium chelatase; ferrochelatase; Metabolism; Biokemi; metabolism;

   Abstract : Magnesium chelatase and ferrochelatase are two very important enzymes, which are involved in chlorophyll and heme biosynthesis, respectively. They both use protoporphyrin IX as substrate but magnesium chelatase inserts a magnesium ion whereas ferrochelatase inserts a ferrous ion. These two enzymes have been studied in this thesis. READ MORE

5. 3. Iron in Haem Biosynthesis. Structural Studies of Ferrochelatase and Frataxin

   Author : Tobias Karlberg; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; Molekylär biofysik; Molecular biophysics; Biomedicinska vetenskaper; Biomedical sciences; protein crystallography; ferrochelatase; haem biosynthesis; iron; frataxin;

   Abstract : Ferrochelatase catalyses the synthesis of heme by inserting Fe(II) into protoporphyrin IX. The structure of ferrochelatase from yeast has been determined (2.4 Å). The structure is homodimeric with each of the monomer made up of two Rossmann type domains with an active-site cleft between them. READ MORE

6. 4. Structural and physicochemical studies on metal and porphyrin binding by the Bacillus subtilis ferrochelatase

   Author : Mattias Hansson; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; metal specificity; metal binding; porphyrin metallation; time resolved crystallography; fluorescence quenching; X-ray structure; inclusion bodies; Bacillus subtilis; heme biosynthesis; ferrochelatase; hemH;

   Abstract : The enzyme ferrochelatase (EC 4.99.1.1) is the terminal enzyme in the biosynthetic pathway of heme b and catalyzes the insertion of Fe(II) into protoporphyrin IX. READ MORE

7. 5. Theoretical studies of porphyrin proteins

   Author : Emma Sigfridsson; Beräkningskemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular mechanics; quantum chemical calculations; electrostatic potential charges; atomic charges; ferrochelatase; cytochrome; myoglobin; Porphyrin; haem; QM MM; reorganisation energy; Theoretical chemistry; quantum chemistry; Teoretisk kemi; kvantkemi;

   Abstract : Different aspects of porphyrin proteins have been studied with theoretical methods. For example, we have studied: - The importance of hydrogen bonds for the discrimination between carbon monoxide and molecular oxygen by myoglobin, the oxygen carrier in muscles, modelling the active site both in vacuum and in the protein matrix - The inner-sphere reorganisation energy during electron transfer for cytochromes compared to other electron-transfer proteins, such as blue copper proteins and Fe-S clusters - The role of porphyrin distortions in the reaction mechanism of ferrochelatase, the enzyme that inserts an iron ion into protoporphyrin IX to make haem - The interaction between different metal sites in ferrochelatase In these studies we have used density functional theory, classical force field methods, and a combination of quantum chemistry and molecular mechanics. READ MORE