Search for dissertations about: "fetal rejection"

Showing result 1 - 5 of 18 swedish dissertations containing the words fetal rejection.

2. 1. Xenograft Rejection : A Study of Cytokine mRNA Expression in Experimental Models

   Author : Henrik Krook; Anthony Dorling; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Type 1 diabetes; Parkinson’s disease; xenotransplantation; islets; neural tissue; heart; mRNA; cytokines; rejection.; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

   Abstract : Acute cellular xenograft rejection of ICCs triggered mRNA expression of proinflammatory cytokines (IL-1b and TNF-a), Th1 associated cytokines (IL-12p40, IL-2 and IFN-g) and Th2 associated cytokines (IL-4 and IL-10). The peak values and the kinetics of the mRNA expression indicated that acute cellular xenograft rejection is enhanced by the proinflammatory response and mediated by the Th1 associated response, whereas the function of the Th2 associated response most likely is to counteract the Th1 associated cytokines and thereby inhibit bystander damage by the delayed type hypersensitivity like rejection process. READ MORE

4. 2. Rejection and Immunosuppression at Uterus Transplantation: an experimental study in rodents

   Author : Klaus Groth; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; uterus; transplantation; rejection; cyclosporine A;

   Abstract : Uterus transplantation is developed as a possible treatment for patients with absolute uterine factor infertility. There has been one attempt to transplant a human uterus, which however failed and more basic research is needed before another attempt is performed. READ MORE

5. 3. Immunological aspects of maternal-foetal interactions in mice

   Author : Marie Arvola; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Neonatal mice; milk; placenta; fetal rejection; IgG; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

   Abstract : Mammalian pregnancy is an immunological paradox. The foetus, which expresses both paternal and maternal cell-surface molecules, has to be protected from rejection by the maternal immune system. At the same time, the mother has to have an efficient immune defence and must provide her offspring with antibodies. READ MORE

6. 4. Women's Experiences of Fetal Screening for Down's Syndrome by Means of an Early Ultrasound Examination

   Author : Susanne Georgsson Öhman; Ulla Waldenström; Charlotta Grunewald; Berit Schei; Sophiahemmet Högskola; Karolinska Institutet; Karolinska Institutet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fetal ultrasound screening; Nuchal translucency; Down s syndrome; Worry; Depressive symptoms; False positive results; Women s reactions; Risk information; Nursing; Omvårdnad; Fetal ultrasound screening; nuchal translucency; Down s syndrome; worry; depressive symptoms; false positive results; women s reactions; risk information;

   Abstract : The general aim of this thesis was to explore women's reactions to and experiences of fetal screening for Down's syndrome PS) by means of an ultrasound examination, including measurement of fetal nuchal translucency (NT). The effect of this screening on maternal worry about the baby's health was investigated, as well as reactions to a false positive test and interpretation of information about riskAlso, an instrument measuring worry during pregnancy, the Cambridge Worry Scale, was translated into Swedish and tested on a sample of pregnant women. READ MORE

7. 5. Islet xenograft rejection : studies in the pig-to-rodents and pig-to-primate models

   Author : Lars Wennberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Xenotransplantation; islets; rejection; porcine; immunosuppression; C-peptide;

   Abstract : The aims of this thesis was: 1) to compare islet allo- and xenograft rejection in rats, using immunosuppression with CsA in a mixed allogeneic-xenogeneic islet transplantation model, 2) to evaluate the efficacy of various immunosuppressive drugs, with special reference to Leflunomide, in preventing islet xenograft rejection in the pig-to-rat model, 3) to perform an immunohistochemical study of porcine islet xenograft rejection in primates including primates treated with CsA+DSG, and 4) to study the metabolism and excretion of porcine C-peptide in mice, with special reference to the use of donor-specific C-peptide for monitoring islet xenograft function. In summary, the results were as follows: 1. READ MORE