Search for dissertations about: "fibrin gel structure"

Showing result 1 - 5 of 6 swedish dissertations containing the words fibrin gel structure.

2. 1. Studies on fibrin gel structure

   Author : Kamaran T Fatah; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Fibrinogen; fibrin gel structure; plasma; thrombin; fibrinolysis; fibrin gel; zinc ion; plasminogen; crosslinking; acetylsalicylic acid; atherosclerosis; coronary heart disease;

   Abstract : Fibrin gel formation is the final result of interaction between multiple plasma proteins; as a result of activation, fibrinogen is converted to fibrin and crosslinking of fibrin occurs by activated factor XIII, which stabilises the formed clot. Fibrin gel networks were studied in purified fibrinogen systems and in plasma samples from patients with cardiovascular complications and healthy individuals, using light-scattering, turbidity, liquid permeation and confocal 3D microscopy techniques. READ MORE

4. 2. Determination of the overall haemostasis potential and fibrin gel permeability : method development and application in research and in clinical materials

   Author : Aleksandra Antovic; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Global haemostatic assays; overall haemostasis potential; hypercoagulation; hypocoagulation; thrombophilia; haemophilia; fibrin gel porosity; LMMH therapy; acetylsalicylic acid therapy;

   Abstract : We have previously developed a laboratory method that may screen the Overall Haemostasis Potential (OHP) in plasma based on spectophotometric measurement of an area under the fibrin aggregation curve in citrated plasma samples to which tiny amounts of exogenous thrombin and tissue-plasminogen activator (t-PA) are added. When the fibrin aggregation curve is created, the fibrinogen originally present in plasma is gradually converted to fibrin by the generated thrombin. READ MORE

5. 3. Fibrinogen and susceptibility to myocardial infarction : role of gene-gene and gene-environment interactions

   Author : Maria Nastase Mannila; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Atherothrombosis; epistasis; fibrinogen; fibrinogen gamma; fibrin clot structure; haplotypes; myocardial infarction; pleiotropy; SNPs;

   Abstract : Fibrinogen, the precursor of fibrin, is a glycoprotein synthesized in the liver and maintained in plasma at concentrations normally ranging between 2-4 g/L. The fibrinogen molecule consists of two sets of three non-identical polypeptide chains, which are encoded by the fibrinogen gamma (FGG), fibrinogen alpha (FGA) and fibrinogen beta (FGB) genes clustered on chromosome 4. READ MORE

6. 4. Diabetic skin microangiopathy : studies on pathogenesis and treatment

   Author : Majid Kalani; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Diabetes mellitus; chronic foot ulcers; skin microcirculation; peripheral arterial occlusive disease; blood coagulation; fibrinolysis; fibrin gel structure; low molecular weight heparin; dalteparin.;

   Abstract : Background: Most of late diabetic complications have their basis in a disturbed microcirculation, i.e. diabetic microangiopathy. READ MORE

7. 5. Haemostatic changes in plasma for transfusion during preparation and storage

   Author : Anna-Maija Suontaka; Karolinska Institutet; Karolinska Institutet; []
   Keywords : transfusion plasma; cold activation; contact system; coagulation; fibrinolysis; citrates; methylene blue; fibrinogen; stability;

   Abstract : The haemostatic quality of plasma for transfusion is liable to be affected by techniques for preparation and storage. We have studied changes in the contact system, coagulation and fibrinolysis under the following conditions: blood drawn into a half-strength citrate anticoagulant solution, virus inactivation of plasma with methylene blue and red light, and plasma storage in the fluid phase. READ MORE