Search for dissertations about: "fibromodulin"

Showing result 1 - 5 of 10 swedish dissertations containing the word fibromodulin.

  2. 1. Fibromodulin and Dystrophin in Atherosclerosis: Novel roles for extracellular matrix in plaque development

    Author : Annelie Shami; Kärlväggsbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; fibromodulin; dystrophin; carotid artery; lipid accumulation; restenosis; plaque;

    Abstract : Cardiovascular disease represents nearly half the cases of noncommunicable diseases worldwide and is the leading global cause of death. The main underlying cause is atherosclerosis, and in atherosclerotic plaque progression the structure, composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. READ MORE

  4. 2. The role of leucine-rich repeat glycoproteins/proteoglycans in the assembly of collagen matrices

    Author : Liz Svensson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; Skelett; decorin; Collagen; fibromodulin; extracellular matrix; lumican; collagen fibrillogenesis; Skeleton; rheumatology locomotion; muscle system; Biochemistry; Biokemi; Metabolism;

    Abstract : The properties of different connective tissues depend on the synthesis and assembly of macromolecular structures composed of collagen and other extracellular matrix components. Mechanisms modulating these events play important roles in the formation of a functional tissue. READ MORE

  5. 3. The collagen fibrillar network: Sequential degradation of its constituents by tissue metalloproteinases

    Author : Terrence Heathfield; Enheten för led- och mjukvävnadsforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; Metabolism; Biochemistry; collagen; fibromodulin; cartilage; osteoarthritis; Biokemi;

    Abstract : The cartilage matrix is made up of a fibrillar meshwork comprising type II collagen and other associated proteins. One main function of this network is to retain the large aggregating proteoglycan, aggrecan, a vital component in the regulation of fluid flux in cartilage. READ MORE

  6. 4. Fibromodulin and chondroadherin in connective tissue homeostasis

    Author : Viveka Tillgren; Reumatologi och molekylär skelettbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Collagen; integrin; cell surface proteoglycan; extracellular matrix; and small leucine-rich repeat proteoglycan.;

    Abstract : Connective tissue contains a prominent extracellular matrix (ECM), which provides for physiological and mechanical properties. Intra- and inter-molecular interactions between proteins in this ECM provide for the formation of molecular networks. These interactions determine the shape of the tissue as well as cell behavior. READ MORE

  7. 5. Studies on the extracellular matrix of the dysfunctional pelvic floor

    Author : Marie Westergren Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Pelvic floor; pelvic organ prolapse; stress urinary incontinence; extracellular matrix; collagen; SLRPs; decorin; lumican; fibromodulin; elastin associated proteins; fibrillin-1; fibulin-5; sex steroid hormone receptors; ER; PR; AR;

    Abstract : Objective: Pelvic floor dysfunction cause impaired quality of life of many women and is one of the most common reasons for gynaecological surgery on benign indications. Little is known about the pelvic floor extracellular matrix as a pre-requisite for mechanical sustainability through vaginal delivery, age and hormonal changes. READ MORE