Search for dissertations about: "folate metabolism"

Showing result 1 - 5 of 23 swedish dissertations containing the words folate metabolism.

2. 1. Examining the role of metabolism in Myc-driven tumorigenesis

   Author : Tacha Zi Plym Forshell; Jonas Nilsson; Mattias Belting; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cancer; Myc; metabolism; polyamines; spermidine synthase; glycolysis; lactate dehydrogenase; serine metabolism; Phgdh; folate metabolism; Shmt; Pim kinase; Pim-3 Kinase; Molecular biology; Molekylärbiologi;

   Abstract : Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, differentiation, and angiogenesis.  MYC expression is deregulated in many types of human cancer; therefore discovering the mechanisms behind MYCs role in tumorigenesis is essential. READ MORE

4. 2. Folate, Hormones and Infertility : Different factors affecting IVF pregnancy outcome

   Author : Tiina Murto; Anneli Stavreus-Evers; Agneta Skoog Svanberg; Sven-Eric Olsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Folate; folic acid supplement; homocysteine; hormones; infertility; IVF; lifestyle factor; MTHFR; predictive value; socioeconomic factor; women; Obstetrik och gynekologi; Obstetrics and Gynaecology;

   Abstract : Various hormones have been studied as regards prediction of pregnancy outcome after infertility treatment, but no ideal candidate has been found. Folate and genetic variations in folate metabolism have also been associated with infertility, but it remains unclear how these factors affect IVF pregnancy outcome. READ MORE

5. 3. Biomarkers of one-carbon metabolism in colorectal cancer risk

   Author : Björn Gylling; Richard Palmqvist; Katarina Bälter; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; one-carbon metabolism; biomarkers; folate; epidemiology; Cancer Epidemiology; cancerepidemiologi;

   Abstract : One-carbon metabolism, a network of enzymatic reactions involving the transfer of methyl groups, depends on B-vitamins as cofactors, folate as a methyl group carrier, and amino acids, betaine, and choline as methyl group donors. One-carbon metabolism influences many processes in cancer initiation and development such as DNA synthesis, genome stability, and histone and epigenetic methylation. READ MORE

6. 4. Folate - Associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status

   Author : Ulrika Ericson; Diabetes - kardiovaskulär sjukdom; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; folate; B-vitamins; breast cancer; diet; epidemiology; nutrition; plasma; polymorphism; estrogen receptor α; estrogen receptor β; reproducibility; prospective;

   Abstract : Folate is a B-vitamin that may influence cancer development via its role as methyl donor for DNA synthesis and methylation. Plant foods contain many bioactive compounds including folate and fiber. Results from the Malmö Diet and Cancer (MDC) cohort indicate lower breast cancer risk at high fiber intake. READ MORE

7. 5. Vascular mechanisms in dementia with special reference to folate and fibrinolysis

   Author : Nils-Olof Hagnelius; Torbjörn K. Nilsson; Teodoro Bottiglieri; Örebro universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dementia; Alzheimer’s disease; vascular dementia; folate; homocysteine; vitamin B12; CSF Serum folate ratio; fibrinolysis; tPA; PAI-1; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi; MEDICINE; MEDICIN; Geriatrik; Geriatrics; Medicin; Medicine;

   Abstract : The aim of this thesis was to study the biomarker homocysteine and other novel potential vascular risk factors for dementia. In an out-patient based study of a cohort of 926 consecutive subjects referred to our Memory Unit during 1996―2000, serum-folate was lower and total plasma homocysteine (tHcy) and serum methyl malonate were higher in subjects being prescribed with B12. READ MORE