Search for dissertations about: "forkhead genes"
Showing result 1 - 5 of 20 swedish dissertations containing the words forkhead genes.
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1. Human Forkhead Genes
Abstract : The forkhead family constitutes a group of genes which encodes transcription factors that share a common DNA-binding domain, the forkhead domain. The first member to be discovered was the Drosophila melanogaster gene fork head. Members of this family have been found in a variety of species from bakers' yeast to man. READ MORE
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2. Forkhead Genes in Mammalian Development
Abstract : This thesis concerns aspects of Forkhead gene biology and it’s relation to mammalian development. Genes from three subclasses are discussed, Foxj3, Foxf1 and f2, and Foxe3. READ MORE
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3. Functional studies of two forkhead genes
Abstract : Forkhead genes are functionally diverse and several have been linked to human disease. A previous screen for forkhead genes identified the family member FOXS1. To characterize the function of this gene, we produced a mouse model in which the Foxs1 gene was replaced by a lacZ marker allele. READ MORE
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4. Foxf2 and Foxc2, two transcription factors that regulate adipocyte metabolism
Abstract : Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many countries. Diet-induced insulin resistance plays a central role in the development of type 2 diabetes. READ MORE
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5. FoxF genes in development and disease
Abstract : Forkhead transcription factors of the FoxF group are important during embryonic de-velopment, and mutation of either of the members, Foxf1 and Foxf2, has fatal conse-quences. In this thesis, I present our recent findings about the mechanism of action of FoxF genes in development and disease. READ MORE