Search for dissertations about: "fractionation sensitivity"

Showing result 1 - 5 of 17 swedish dissertations containing the words fractionation sensitivity.

  2. 1. Searching for the optimal radiotherapy treatment time, dose and fractionation - the role of hypoxia and reoxygenation : A modelling study

    Author : Emely Lindblom; Iuliana Toma-Dasu; Ingmar Lax; Ludvig Paul Muren; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hypoxia; Reoxygenation; SBRT; Fractionation; Medical Radiation Physics; medicinsk strålningsfysik;

    Abstract : The search for the optimal choice of treatment time, dose and fractionation regimen is one of the major challenges in radiation therapy. Several aspects of the radiation response of tumours and normal tissues give different indications of how the parameters defining a fractionation schedule should be altered relative to each other which often results in contradictory conclusions. READ MORE

  4. 2. Radiobiological end-points for the theoretical evaluation of the effectiveness of carbon ions and photons in treating tumours with dynamic hypoxia

    Author : Antonovic Laura; Iuliana Toma-Dasu; Tatsuaki Kanai; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; OER; hypoxia; LOC; RCR; hypofractionation; SBRT; carbon ion; fractionation; TCP; SF; RCE; RBE; Medical Radiation Physics; medicinsk strålningsfysik;

    Abstract : Tumours are characterised by unorganised vasculature, which often results in hypoxic regions. Hypoxia is a common cause for photon radiotherapy (RT) treatment failure, as hypoxic cells require up to 2-3 times higher doses compared to well-oxygenated cells for the same effect in terms of cell kill. READ MORE

  5. 3. Modelling late toxicity in hypofractionated radiation therapy

    Author : Niclas Pettersson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hypofractionation; normal tissue complication probability; modelling; linear-quadratic model; fractionation sensitivity; late toxicity; radiation-induced rib fracture; genitourinary toxicity; stereotactic body radiation therapy; high-dose-rate brachytherapy; multimodality radiation therapy; patient-reported outcomes; prostate cancer; nsclc;

    Abstract : In hypofractionated radiation therapy (RT), the treatment is delivered by few fractions with high doses per fraction. This is in contrast to conventionally fractionated RT where the total dose is delivered in many fractions with low doses per fraction. READ MORE

  6. 4. Isotope Ratio and Trace Element Measurements Using Inductively Coupled Plasma – Mass Spectrometry : Method Development and Applications in Environmental Forensics

    Author : Simon Pontér; Anders Widerlund; Hjalmar Laudon; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Isotope ratio measurements; screening analysis; ICP-MS; MC-ICP-MC; multi-tracer studies; fractionation; Environmental Forensics; Tracing; Tillämpad geokemi; Applied Geochemistry;

    Abstract : Environmental Forensics is a scientific methodology developed for identifying sources, the timing of release, and transport pathways for potentially hazardous environmental contaminants. It combines a variety of analytical methods with principles derived from disciplines such as chemistry, geology, geochemistry, hydrogeology, and statistics, with the purpose to provide objective scientific and legal conclusions on the source and/or time of a contaminant release. READ MORE

  7. 5. Mass spectrometry-based proteomic strategies applied to Helicobacter pylori. A Search for candidate vaccine antigens

    Author : Elisabet Carlsohn; Göteborgs universitet; []
    Keywords : proteomics; mass spectrometry; Helicobacter pylori; membrane proteins; nano-liquid chromatography; subcellular fractionation;

    Abstract : This thesis describes the development and refinement of proteomic strategies and the application of these on the human gastric pathogen H. pylori. The purpose was to identify proteins, and in particular membrane proteins, as potential targets for vaccine development. READ MORE