Search for dissertations about: "fragment based drug discovery"
Showing result 1 - 5 of 9 swedish dissertations containing the words fragment based drug discovery.
-
1. Fragment Based Drug Discovery with Surface Plasmon Resonance Technology
University dissertation from Uppsala : Acta Universitatis UpsaliensisAbstract : Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. READ MORE
-
2. Introducing weak affinity chromatography to drug discovery with focus on fragment screening
University dissertation from Växjö : Linnaeus University PressAbstract : Fragment-based drug discovery is an emerging process that has gained popularity in recent years. The process starts from small molecules called fragments. One major step in fragment-based drug discovery is fragment screening, which is a strategy to screen libraries of small molecules to find hits. READ MORE
-
3. Revealing Secrets of Synaptic Protein Interactions A Biosensor based Strategy
University dissertation from Uppsala : Acta Universitatis UpsaliensisAbstract : Protein interactions are the basis of synaptic function, and studying these interactions on a molecular level is crucial for understanding basic brain function, as well as mechanisms underlying neurological disorders. In this thesis, kinetic and mechanistic characterization of synaptic protein interactions was performed by using surface plasmon resonance biosensor technology. READ MORE
-
4. Discovery and evaluation of direct acting antivirals against hepatitis C virus
University dissertation from Uppsala : Acta Universitatis UpsaliensisAbstract : Until recently, the standard therapy for hepatitis C treatment has been interferon and ribavirin. Such treatment has only 50% efficacy and is not well tolerated. The emergence of new drugs has increased the treatment efficacy to 90%. READ MORE
-
5. Towards a New Generation of Anti-HIV Drugs Interaction Kinetic Analysis of Enzyme Inhibitors Using SPR-biosensors
University dissertation from Uppsala : Acta Universitatis UpsaliensisAbstract : As of today, there are 25 drugs approved for the treatment of HIV and AIDS. Nevertheless, HIV continues to infect and kill millions of people every year. Despite intensive research efforts, both a vaccine and a cure remain elusive and the long term efficacy of existing drugs is limited by the development of resistant HIV strains. READ MORE
