Search for dissertations about: "fragment"
Showing result 1 - 5 of 519 swedish dissertations containing the word fragment.
-
1. Fragment-based drug discovery : Novel methods and strategies for identifying and evolving fragment leads
Abstract : The need for new drugs became ever more apparent in the year 2020 when the world was faced with a viral pandemic. How drugs are discovered and their relevance to society became part of daily discussions in workplaces and homes throughout the world. Consequently, efficient strategies for preclinical drug discovery are clearly needed. READ MORE
-
2. Introducing weak affinity chromatography to drug discovery with focus on fragment screening
Abstract : Fragment-based drug discovery is an emerging process that has gained popularity in recent years. The process starts from small molecules called fragments. One major step in fragment-based drug discovery is fragment screening, which is a strategy to screen libraries of small molecules to find hits. READ MORE
-
3. Concrete Structures Subjected to Fragment Impacts
Abstract : As concrete is commonly used for protective structures, how a blast wave and fragment impacts from an explosion affect the concrete is an important issue. Concrete subjected to explosive loading responds very differently from statically loaded structures. READ MORE
-
4. Towards a New Generation of Anti-HIV Drugs : Interaction Kinetic Analysis of Enzyme Inhibitors Using SPR-biosensors
Abstract : As of today, there are 25 drugs approved for the treatment of HIV and AIDS. Nevertheless, HIV continues to infect and kill millions of people every year. Despite intensive research efforts, both a vaccine and a cure remain elusive and the long term efficacy of existing drugs is limited by the development of resistant HIV strains. READ MORE
-
5. Cartilage destruction - Release of type IX collagen in joint disease
Abstract : Cartilage is of vital importance for the function of joints. It is characterized by a prominent extracellular matrix (ECM) that is produced and maintained by relatively few cells of one type, the chondrocyte. READ MORE