Search for dissertations about: "functional association"
Showing result 1 - 5 of 499 swedish dissertations containing the words functional association.
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1. Functional association networks for disease gene prediction
Abstract : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. READ MORE
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2. Global functional association network inference and crosstalk analysis for pathway annotation
Abstract : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. READ MORE
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3. Inference of functional association networks and gene orthology
Abstract : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. READ MORE
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4. Variations in Functional Lateralization
Abstract : The general aim of this thesis was to study asymmetric activation of the neocortex in normal subjects, using the rCBF technique and different cognitive tasks. The aim was also to study individual and group variations of asymmetric activation, as well as factors pertaining to these variations. The thesis is based on four investigations. READ MORE
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5. Dissecting the Genetic Basis of Systemic Lupus Erythematosus : The Pursuit of Functional Variants
Abstract : Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease that primarily affects women during the childbearing years. SLE is characterized by the production of autoantibodies against nucleic acids and their interacting proteins. READ MORE