Search for dissertations about: "galanin receptor 2 overexpressing mice"

Found 3 swedish dissertations containing the words galanin receptor 2 overexpressing mice.

  2. 1. The galanin type 2 receptor: molecular biological, histochemical and electrophysiological studies

    Author : Kang Zheng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Galanin;

    Abstract : In the present thesis, the aim was to probe the distribution and functions of galanin type 2 receptor (GalR2) in the rodent brain. In order to overcome the lack of a reliable antibody to localize GalR2 by immunohistochemistry, we generated a construct which expresses GalR2 tagged with enhanced GFP (EGFP). READ MORE

  4. 2. Galanin receptor subtypes in rodent models of mood disorders

    Author : Tara Wardi-Le Maitre; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 5-HT1A receptor; galanin; galanin receptor 2 overexpressing mice; locus coeruleus; dorsal raphe; depression-like behavior; forced swim test;

    Abstract : Major depressive disorder (MDD) is a serious mental illness, with a complex etiology. It is a multifactorial disorder caused by a combination of genetic, environmental and epigenetic factors. Exposure to stressful life events seems to be a common, contributing cause of morbidity. READ MORE

  5. 3. Brain galanin sytems and their role in depression-like behaviour

    Author : Eugenia Kuteeva; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 5-HT1A receptor; depression-like behaviour; forced swim test; galanin; galanin-overexpressing; galanin receptor; noradrenaline; serotonin; transgenic mouse;

    Abstract : The aim of the present thesis was to investigate the role of the neuropeptide galanin and galanin receptor subtypes in behavioural functions with a particular focus on depression-like behaviour. In agreement with its wide distribution in the central nervous system, galanin has been implicated in various functions, including regulation of reproduction, endocrine functions, antinociception, attention, learning and memory as well as regulation of mood. READ MORE