Search for dissertations about: "galectins"
Showing result 1 - 5 of 23 swedish dissertations containing the word galectins.
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1. Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins
Abstract : Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders. READ MORE
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2. Studies on Peripheral Nerve Regeneration: Microdispensing, Neurite Guidance and Galectins
Abstract : The present thesis describes development of a microdispenser-based technique to create of protein patterns for neurite guidance. The same technique was also developed to allow direct positioning of dissociated cells, including neurons, on cell culture substrates. Finally the role of galectin-3 and 8 during nerve regeneration was investigated. READ MORE
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3. Small-Molecule Galectin Ligands : Structure-Based Optimisation of Affinity and Selectivity
Abstract : In the body, all cell surfaces are covered with glycans, and many regulatory components havecarbohydrates attached to them, which can aid in their function. Galectins are a family of proteins whichcan bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of cellularprocesses. READ MORE
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4. Galectin Inhibitors – Molecular Tools in Biomedical Research and Clinical Implications
Abstract : Galectins are β-galactoside-binding lectins, which are present in both the intracellular and extracellular environments of cells. During the last two decades, galectins have gained increasing interest as drug targets in various diseases, such as chronic inflammation (fibrosis) and cancer, in which galectins have been shown to play important, and sometimes rate-limiting, roles. READ MORE
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5. Design and Synthesis of Galectin Inhibitors
Abstract : Galectins, a lectin family, have shown binding affinities towards b-galactosides. Galectins have been proposed to be involved in a wide range of functions like for example, cell growth, adhesion, migration, chemo taxis and apoptosis. They have also been associated with various cancer types. READ MORE