Search for dissertations about: "gamma-aminobutyric acid receptor A"

Showing result 1 - 5 of 13 swedish dissertations containing the words gamma-aminobutyric acid receptor A.

  2. 1. Insulin promotes GABA signalling modulation in both the mouse hippocampus and human CD4+ T cells

    Author : Hayma Hammoud; Bryndis Birnir; Fredrik Elinder; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gamma-aminobutyric acid; hippocampus; tonic currents; CD4 T cells; glucose; insulin; cytokines; proliferation.; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Gamma-aminobutyric acid (GABA) is the most common inhibitory neurotransmitter in the adult mammalian brain, where it mediates several biological functions. Rapid inhibition is predominantly mediated by the activation of GABA-A receptors that are ubiquitously expressed across the central nervous system in a cell-, circuit-, or region-specific manner. READ MORE

  4. 2. The GDNF-receptor GFR-alpha-1 : neural expression patterns and regulation in stroke

    Author : Arezou Sarabi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : G DNF; GFR-alpha-1 Strok; . Ischemia; receptors; calcium-binding proteins; gamma- aminobutyric acid; glutamic acid decarboxylase; dopamine; Parkinson s disease;

    Abstract : Background: Neurotrophic factors in the mammalian nervous system are important for development and survival of neurons and for maintenance and plasticity of synaptic connections. Additionally, they have been shown to prevent neurodegeneration after damage to the central nervous system (CNS). READ MORE

  5. 3. Ovarian hormones and effects in the brain : studies of neurosteroid sensitivity, serotonin transporter and serotonin2A receptor binding in reproductive and postmenopausal women

    Author : Anna-Carin Wihlbäck; Tord Naessén; Umeå universitet; []
    Keywords : estradiol; progesterone; progestin; neurosteroids; saccadic eye velocity; sedation; hormone replacement therapy HRT ; menopause; menstrual cycle; mood; serotonin; paroxetine; lysergic acid diethylamide; platelets; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background: Estrogen has been reported to enhance well-being and quality of life during the climacteric phase. In women with an intact uterus estrogen treatment is always combined with progestins in order to protect the endometrium from hyperplasia and malignancies. READ MORE

  6. 4. Simulating Functional Cycles and Drug Modulation in Ligand-gated Ion Channels

    Author : Yuxuan Zhuang; Erik Lindahl; Grace Brannigan; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ion channels; molecular dynamics; markov state model; lipid modulation; nicotinic receptor; protein conformational transitions; Biophysics; biofysik;

    Abstract : Understanding the intricate motions and conformational changes that govern biological processes remains a fascinating and challenging endeavor. The research presented in this thesis aims to elucidate the dynamic processes underlying biological functions, specifically focusing on the dynamics of pentameric ligand-gated ion channels (pLGICs), which play a crucial role in signal transduction within the brain. READ MORE

  7. 5. Allopregnanolone effects on food intake and weight gain

    Author : Ellinor Holmberg; Torbjörn Bäckström; Bo Söderpalm; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allopregnanolone; neurosteroid; GABA; GABAA receptor; food intake; weight gain; obesity; hyperphagia; diurnal rhythm; schedule feeding; high fat diet; electrophysiology; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background Obesity is currently one of the major causes of ill health and it is clear that overeatingis the cause of obesity. However, the actions of many endogenous factors that contribute to overeating are still not well understood. READ MORE