Search for dissertations about: "gene silencing"

Showing result 1 - 5 of 192 swedish dissertations containing the words gene silencing.

  2. 1. Mechanisms of Transgene Silencing in Neural Cells -Implications for Ex Vivo Gene Therapy to the Brain

    Author : Nina Rosenqvist; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; Neurology; neuropsychology; ChIP; rat; transgene; insulator; differentiation; GFP; lentivirus; DNA methylation; histone deacetylation; chromatin; expression; silencing; stem cell; progenitor; gene therapy; neurofysiologi; neuropsykologi; CNS; transplantation;

    Abstract : The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. READ MORE

  4. 2. Gene silencing and expression during mammalian development : The special case of the imprinted H19 gene

    Author : Kristian Svensson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Biology; Biologi; zoologisk utvecklingsbiologi; Animal Development;

    Abstract : Embryonic development consists of a vast number of fine-tuned, complex processesthat organise the body plan and individual organs. To enable developmental decisions,genes pivotal for normal development must be stably activated and silenced, asappropriate. READ MORE

  5. 3. Molecular Insights into Kcnq1ot1 Noncoding Antisense RNA Mediated Long Range Transcriptional Gene Silencing

    Author : Radha Raman Pandey; Chandrasekhar Kanduri; Karl Ekwall; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epigenetics; gene silencing; noncoding RNA; genomic imprinting; Kcnq1ot1; Medical genetics; Medicinsk genetik;

    Abstract : Non-coding antisense RNAs have been implicated in the epigenetic silencing of individual gene as well as chromosomal domains. While silencing of the overlapping gene by antisense RNAs has been well investigated, their functional role in silencing of chromosomal domains remains enigmatic. READ MORE

  6. 4. Gene silencing mechanisms in Phytophthora infestans

    Author : Vetukuri Ramesh; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : The hemibiotrophic oomycete, Phytophthora infestans, causes late blight on potato and tomato. This destructive pathogen is well known for the rapidity with which it overcomes host resistance. This thesis focuses on the molecular basis of gene (RNA) silencing in P. infestans and the role it may have in its genome biology and pathogenesis. READ MORE

  7. 5. Chromatin Dynamics in the Fission Yeast, Schizosaccharomyces pombe

    Author : Carolina Kristell; Pernilla Bjerling; Per Sunnerhagen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chromatin; Gene induction; Silencing; Subnuclear localization; Stress; Molecular biology; Molekylärbiologi; Molekylär genetik; Molecular Genetics;

    Abstract : In the eukaryotic cell nucleus, spatial organization and dynamics of the genome is important in the regulation of gene expression. This thesis describes the use of the fission yeast, Schizosaccharomyces pombe, to study chromatin regulation and dynamics. We used nitrogen starvation to induce transcription of genes in fission yeast cells. READ MORE