Search for dissertations about: "gene targeting"
Showing result 1 - 5 of 393 swedish dissertations containing the words gene targeting.
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1. Conditional targeting of the PDGF-B gene
Abstract : Platelet derived growth factors (PDGF) are known as mitogens for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. Previous in vivo analyses have shown that PDGF-B is necessary for normal embryonic development and life after birth, but the relative importance of the various cellular sources of PDGF-B during development has not been clarified. READ MORE
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2. Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy
Abstract : Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack of suitable vectors. READ MORE
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3. New Conditional Gene Targeting Methods : For Studying Neurotrophic Mechanisms in Selected Neuronal Populations
Abstract : Powerful techniques to manipulate the mouse genome have had a great impact on our understanding of biology. The major drawback with conventional transgenic methods is that the genetic alteration will be present in every cell of the animal, from conception and onwards. READ MORE
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4. From GWAS to gene : Zebrafish as a model system for large-scale studies of obesity and comorbidities
Abstract : Obesity increases the risk of developing comorbidities such as cardiovascular and metabolic diseases. However, not all obese individuals develop comorbidities, and those that do not are referred to as “metabolically healthy obesity” individuals. READ MORE
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5. Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis
Abstract : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. READ MORE