Search for dissertations about: "gene transfer agent"
Showing result 1 - 5 of 9 swedish dissertations containing the words gene transfer agent.
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1. Hidden Diversity Revealed : Genomic, Transcriptomic and Functional Studies of Diplomonads
Abstract : The diplomonads are a diverse group of eukaryotic microbes found in oxygen limited environments such as the intestine of animals were they may cause severe disease. Among them, the prominent human parasite Giardia intestinalis non-invasively colonizes the small intestine of humans and animals where it induces the gastrointestinal disease giardiasis. READ MORE
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2. Gene therapy in epilepsy: neuropeptides and neurotrophic factors
Abstract : Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach for treatment of TLE. READ MORE
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3. Genome Evolution and Host Adaptation in Bartonella
Abstract : Bacteria of the genus Bartonella infect the red blood cells of a wide range of wild and domestic mammals and are transmitted between hosts by blood-sucking insects. Although most Bartonella infections are asymptomatic, the genus contains several human pathogens. READ MORE
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4. Evolution of symbiotic lineages and the origin of new traits
Abstract : This thesis focuses on the genomic study of symbionts of two different groups of hymenopterans: bees and ants. Both groups of insects have major ecological impact, and investigating their microbiomes increases our understanding of their health, diversity and evolution. READ MORE
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5. Lifestyle and Genome Evolution in Vector-Borne Bacteria : A Comparison of Three Bartonella Species
Abstract : Bacterial genomes provide records of the molecular processes associated with emergence and evolution of different bacterial lifestyles. This thesis is based on whole-genome comparisons within the genus Bartonella, an excellent model system for studies of host- and vector-specificity and infection outcome in animal-associated bacteria. READ MORE