Search for dissertations about: "general pharmacodynamic interaction model"

Found 4 swedish dissertations containing the words general pharmacodynamic interaction model.

  2. 1. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development

    Author : Oskar Clewe; Ulrika S.H. Simonsson; Mats O. Karlsson; Piet van der Graaf; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; PKPD; pharmacometric; nonlinear mixed-effects models; multistate tuberculosis pharmacometric model; general pharmacodynamic interaction model; general pulmonary distribution model; tuberculosis; rifampicin; isoniazid; ethambutol; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent need for new and effective drugs and treatment regimens targeting tuberculosis. The tuberculosis drug development pathway is however not ideal, containing non-predictive model systems and unanswered questions that may increase the risk of failure during late-phase drug development. READ MORE

  4. 2. Pharmacokinetic-Pharmacodynamic Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti-tuberculosis Drugs

    Author : Chunli Chen; Ulrika Simonsson; Mats Karlsson; Sebastian Wicha; Bernd Meibohm; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tuberculosis; pharmacokinetics; pharmacodynamics; pharmacometrics; the Multistate Tuberculosis Pharmacometric model; the General Pharmacodynamic Interaction model; optimized design; rifampicin; isoniazid; ethambutol; pyrazinamide; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Tuberculosis is an ancient infectious disease and a leading cause of death globally. Preclinical research is important for defining drugs and regimens which should be carried forward to human studies. READ MORE

  5. 3. Quantifying effects of antimicrobial drug combinations by modelling and simulation

    Author : Chenyan Zhao; Lena Friberg; Elisabet I. Nielsen; Shampa Das; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics and pharmacodynamics; modelling and simulation; antibiotic combination; model-based translation; antibiotic resistance; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Antibiotic resistance is becoming an accelerating issue, both in the treatment of nosocomial infections and for public health in general. There is a pressing need for innovative methods to understand how available antibiotics could be combined to overcome and limit the emergence of resistance. READ MORE

  6. 4. Treatment of pain behavior after spinal cord injury in rats with special emphasis on the role of adenosine receptors

    Author : Margareta von Heijne; Karolinska Institutet; Karolinska Institutet; []
    Keywords : adenosine; adenosine receptors; allodynia; baclofen; central pain; clonidine; intrathecal; morphine; neuropathic pain; opioid; rat; R-phenylisopropyladenosine; spinal cord injury; tolerance;

    Abstract : Central pain is a form of neuropathic pain occurring after injury or dysfunction in the central nervous system, including the spinal cord. Allodynia (pain to innocuous stimuli) to mechanical and cold stimulation is a common feature of central pain and it is often resistant to treatment. READ MORE