Search for dissertations about: "genetic polymorphism and colorectal cancer risk"

Found 4 swedish dissertations containing the words genetic polymorphism and colorectal cancer risk.

  2. 1. Investigation of immune cell-derived factors as potential biomarkers in patients with colorectal cancer

    Author : Levar Shamoun; Dick Wågsäter; Jan Dimberg; Kalle Landerholm; Blanka Kolodziej; Richard Palmqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene polymorphism; Colorectal cancer; Immunoregulation; Prognosis; Gene and protein expression; Survival; Zmynd15; Genpolymorfism; Kolorektal cancer; Immunreglering; Prognos; Gen- och proteinuttryck; Överlevnad; Zmynd15; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Medical Cell Biology; Medicinsk cellbiologi; Patologi; Pathology;

    Abstract : Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer related death. It is a heterogeneous disease involving multiple molecular pathways that result in differing phenotypes. Individual variability in CRC susceptibility is influenced by genetic variation, such as single nucleotide polymorphisms (SNPs). READ MORE

  4. 2. CYP2W1 in colorectal cancer : aspects of risk, prognosis and future treatment options

    Author : Kristina Stenstedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Colorectal cancer (CRC) is a common disease and a major cause of cancer related death globally. Prognosis is rather good in early stages but worse in cases with disseminated disease. There is a constant need of developing all treatment modalities, which also has been done over the last decades. READ MORE

  5. 3. Molecular genetic studies on genes involved in hereditary nonpolyposis colorectal cancer (HNPCC)

    Author : Tao Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : colorectal cancer; endometrial cancer; HNPCC; mismatch repair genes; bhMSH2; hMLH1; hPMS1; hPMS2; hMSH6; mutation screening; MSI; LOH.;

    Abstract : Colorectal cancer (CRC) is a major public health problem in Western countries, and it is the third leading cause of death from cancer in both males and females. Inherited predisposition can be divided into two subgroups based on the absence or the presence of multiple benign colorectal polyps. READ MORE

  6. 4. Colon cancer specific cytochrome P450 2W1 : polymorphism, membrane topology and endogenous roles in development

    Author : Jia Guo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytochrome P450 2W1 (CYP2W1) belongs to a family of drug metabolizing monooxygenases with an unidentified yet endogenous function. CYP2W1 expression pattern has characteristic features of oncofetal genes. Previous studies have shown significant levels of CYP2W1 protein in 30% of human colon cancers and in 50% of corresponding liver metastases. READ MORE