Search for dissertations about: "germ-line gene therapy"
Found 5 swedish dissertations containing the words germ-line gene therapy.
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1. Chosen Children? : An empirical study and a philosophical analysis of moral aspects of pre-implantation genetic diagnosis and germ-line gene therapy
Abstract : With pre-implantation genetic diagnosis (PGD), genetic testing and selective transfer of embryos is possible. In the future, germ-line gene therapy (GLGT) applied to embryos before implantation, in order to introduce missing genes or replace mutant ones, may be possible. READ MORE
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2. B cell repertoire development in normal physiology and autoimmune disease
Abstract : The B cell repertoire in the neonatal immune system (IS) is characterised by reactivity towards self-components, including other immunoglobulin (Ig) V-regions. These properties have been suggested to be a requirement for the development of a normal immune system. READ MORE
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3. Genetic and epigenetic alterations in melanoma
Abstract : Malignant melanoma is a disease that may arise in several different parts of the body, preferentially the skin, rarely in the mucosal membranes or the choroidal tissues of the eye. The incidence of cutaneous melanoma (CMM) is steadily increasing in the Caucasian populations, unlike uveal melanoma (UM) that shows a stable incidence. READ MORE
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4. Genetic and functional studies on the thyroid hormone axis
Abstract : This thesis has two main parts. The first is based on the first three papers with a focus on understanding the etiology and pathogenesis of thyroid malfunction and its effects on different organs. READ MORE
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5. Molecular genetics of cutaneous malignant melanoma
Abstract : Cutaneous malignant melanoma is an aggressive tumor of melanocytes in the skin with rapidly increasing incidence. Patients with advanced disease have a poor prognosis since the tumor is usually resistant to current therapies. Therefore, the development of novel strategies for preventing and treating melanoma is important. READ MORE