Search for dissertations about: "glial scar"

Showing result 1 - 5 of 27 swedish dissertations containing the words glial scar.

  2. 1. To scar or not to scar : origin and function of fibrotic tissue in the central nervous system

    Author : David Oliveira Dias; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : After injury, the adult mammalian central nervous system lacks long-distance axon regeneration, and insufficient repair results in the formation of a multicellular and compartmentalized scar. A great body of work has been dedicated to the study of the glial component of the scar, while the fibrotic lesion core has received less attention. READ MORE

  4. 2. Functions of Pericytes in Ischemic Stroke

    Author : Michaela Roth; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Stroke; Pericytes; RGS5; Blood-brain barrier; vascular remodelling; scar formation;

    Abstract : Ischemic stroke remains one of the leading causes of death and disability worldwide, and its burden is predicted to further increase due to the aging population. The only available treatments, thrombolysis or thrombectomy, can only be applied within a limited time window after stroke onset, and thus are applicable only to a small proportion of stroke patients. READ MORE

  5. 3. On optic nerve injury : experimental studies on axonal regeneration in the adult mammalian CNS

    Author : Marcus Ohlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Astroglia; axon; degeneration; glial scar; immunohistochemistry; macrophage; methylprednisolone; microglia; neurosurgery; optic nerve; rat; regeneration and visual evoked potentials;

    Abstract : Optic nerve injury may occur after a trauma to the head and in many cases it causes partial or total blindness. Today, these patients cannot be offered any specific treatment to restore visual function. READ MORE

  6. 4. Isolation and characterization of adult neural stem cells

    Author : Clas B Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Intermediate filaments; GFAP; nestin; scar formation; regeneration; rodent and human neural stem cells; multipotency.;

    Abstract : Injury to the central nervous system (CNS) is one of man's most handicapping situations resulting in severe functional impairment and in some cases a vegetative state where life is supported artificially. The brain and spinal cord, constituting the CNS, have been viewed for decades as having limited capacity of regeneration with no neurogenesis in the adult. READ MORE

  7. 5. On traumatic lesion to the spinal cord and dorsal spinal roots : factors influencing axonal regrowth across the border between the central and peripheral nervous system in the rat and man

    Author : Tomas Lindholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Immunohistochemistry; in situ hybridization; rat; man; axotomy; regeneration; motoneuron; ; CNS; PNS; tenascin; macrophages; BBB; scar; neuregulin; ErbB3 4; semaphorin; neuropilin; VEGF; olfactory system; DRG; DRT; SNT; SNC.;

    Abstract : Nerve cells are depending on their environment. Glial cells, astrocytes and oligodendrocytes in the central nervous system (CNS) make up a totally different milieu and characteristics than the distinguishing qualities of the peripheral nervous system (PNS), where the nerve cells are surrounded by Schwann cells. READ MORE