Search for dissertations about: "glioblastom"

Found 5 swedish dissertations containing the word glioblastom.

  2. 1. Immunological aspects of intratumoral chemotherapy and immunotherapy in malignant brain tumors

    Author : Julio Enriquez Perez; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma GBM ; Immunotherapy; Mouse glioma; Convection-enhanced delivery; Intratumoral chemotherapy; Glioblastom; Immuneterapi;

    Abstract : Advances in surgery, chemo- and radiotherapy have only modestly improved survival rates of malignant brain tumor patients during the last decades. Emerging evidence suggests that an efficient treatment of malignant brain tumors will likely require the management of multiple aspects of tumor pathobiology in order to manipulate features as tumor heterogeneity and tumor immunosuppression. READ MORE

  4. 2. The quest for new improved adenovirus gene therapy vectors against glioma tumours

    Author : Johan Skog; Göran Wadell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene therapy; virology; adenovirus; glioma; glioblastoma; Genterapi; virologi; adenovirus; gliom; glioblastom; Virology; Virologi;

    Abstract : Gene therapy has received much attention the last decade as a method to correct a number of disorders arising from a defective gene. Gene therapy can be defined as the introduction of a functional genetic element into a cell for a therapeutic purpose. READ MORE

  5. 3. Brain Tumor Imaging and Treatment Effects. Imaging findings and cognitive function in glioblastoma patients

    Author : Anna Rydelius; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; Imaging finding; Quantitative volumetry; Cognitive function; Diffusion tensor imaging DTI ; Treatment effect; Radiotherapy; VMAT; Parametric response maps PRM ; Treatment responce prediction;

    Abstract : AbstractBackground: Glioblastoma is the most common malignant brain tumor. Operation with maximal resection, if feasible, otherwise biopsy followed by radiotherapy and chemotherapy with temozolomide is standard therapy. The prognosis remains poor, with median overall survival being 15 months despite therapy. READ MORE

  6. 4. HAMLET - In vivo effects and mechanisms of tumor-cell death

    Author : Lotta Gustafsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper; Biomedical sciences; proteasome stress; HAMLET; human milk; tumor-cell death; clinical trial; rat xenograft model; skin papilloma; glioblastoma;

    Abstract : HAMLET (human alpha-lactalbumin made lethal to tumor cells), a molecular complex derived from human milk, is an interesting new tool in cancer research since it induces programmed cell death in tumor cells while leaving normal, differentiated cells unharmed. The in vivo effects of HAMLET were studied in a rat xenograft model of human glioblastoma. READ MORE

  7. 5. The Spatial Context – through the lens of method development

    Author : Linda Kvastad; Joakim Lundeberg; Lars Feuk; KTH; []
    Keywords : RNA; RNA-sequencing; transcriptomics; spatial transcriptomics; single cells; pediatric brain tumors; Spatial RIN; Bioteknologi; Biotechnology;

    Abstract : In the present moment of time, we find ourselves in a period where the advancement of genomic tools is progressing at a fast pace. Of particular interest for this thesis is the study of gene activity. READ MORE