Search for dissertations about: "glomerulosclerosis"

Showing result 1 - 5 of 13 swedish dissertations containing the word glomerulosclerosis.

  2. 1. Pathomechanism of diabetic nephropathy

    Author : Anna Körner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : diabetic nephropathy; hyperflltration; Na ; K - ATPase; Dahl rats; salt sensitive hypertension; glomerulosclerosis; polyol pathway activation; oxidative stress;

    Abstract : Diabetic nephropathy is today the most common cause of end stage renal failure. The risk for developing overt diabetic nephropathy is considerably reduced by antihypertensive treatment, and adequate control of blood glucose. However, there is a need for additional and even more efficient tools to prevent this complication of diabetes. READ MORE

  4. 2. Chronic kidney disease of unknown etiology in Central America and Sri Lanka : renal morphology and clinical characteristics

    Author : Julia Wijkström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Chronic kidney disease (CKD) is a global health problem. The most common etiologies of CKD are diabetes mellitus, hypertension, and glomerulonephritis, but over the last several decades a high prevalence of CKD of unknown etiology (CKDu) has been reported from rural communities in some tropical countries, including Central America, and Sri Lanka. READ MORE

  5. 3. A Podocyte view on RhoGTPases and actin cytoskeleton regulation

    Author : Lovisa Bergwall; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Podocyte; RhoGTPases; Actin cytoskeleton regulation;

    Abstract : Proteinuria is a hallmark symptom of chronic kidney disease, that if left to persist constitutes a risk for progression of disease. Symptomatic treatment aiming at decreasing proteinuria is therefore standard practice. READ MORE

  6. 4. The role of melanocortin 1 receptor in kidney disease

    Author : Annika Lindskog Jonsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nephrotic syndrome; proteinuria; adrenocorticotropic hormone; melanocortin 1 receptor; podocytes;

    Abstract : Nephrotic syndrome is a term describing a group of poorly understood glomerular diseases that are responsible for a steadily increasing number of patients requiring active uremic care. Characteristic symptoms of nephrotic syndrome are proteinuria, hypoalbuminemia, hyperlipidemia and peripheral edema, and treatment of these symptoms, rather than their cause, is currently the only option available to the clinician. READ MORE

  7. 5. Role of extracellular retention of platelet-derived growth factor-B. Functions in development and disease

    Author : Per Lindblom; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; pericyte; cancer; fibrosis; ECM; HSPG; cell retention; endothelial;

    Abstract : During development, the cell secretes growth and differentiation factors (GDFs) to the surrounding microenvironment. These factors are often key regulators of organogenesis and embryogenesis. Several GDFs carry sequences that mediate specific interaction with molecules of the extracellular matrix (ECM) that surrounds the cell. READ MORE