Search for dissertations about: "glucose uptake"

Showing result 1 - 5 of 225 swedish dissertations containing the words glucose uptake.

  2. 1. Glucose and lipid metabolism in insulin resistance : an experimental study in fat cells

    Author : Jonas Burén; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; adipocyte; insulin resistance; type 2 diabetes; insulin signalling; glucose uptake; insulin; glucose; dexamethasone; insulin receptor substrate; protein kinase B; GLUT4; lipoprotein lipase; Folkhälsomedicin; Public health medicine research areas; Folkhälsomedicinska forskningsområden; medicin; Medicine;

    Abstract : Type 2 diabetes is usually caused by a combination of pancreatic β-cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterised by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. READ MORE

  4. 2. Fat cell insulin resistance : an experimental study focusing on molecular mechanisms in type 2 diabetes

    Author : Frida Renström; Jan Eriksson; Anna Krook; Umeå universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; adipocyte; insulin signaling; insulin; glucose; IRS-1; glucose uptake; insulin resistance; typ 2 diabetes; serum; Medicine; Medicin;

    Abstract : The aim of the present thesis was to further increase our understanding of mechanisms contributing to and maintaining cellular insulin resistance in type 2 diabetes (T2D). For this reason, the effects of high glucose and insulin levels on glucose transport capacity and insulin signaling, with emphasis on insulin receptor substrate 1 (IRS-1) were assessed in fat cells. READ MORE

  5. 3. Effects of acute metabolic interventions on hemodynamics, endothelial function and forearm glucose uptake

    Author : Andreas Fugmann; Uppsala universitet; []
    Keywords : Medical sciences; Insulin; glucose; lipids; bloodflow; endothelium; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Hyperinsulinemia is known to augment endothelium-dependent.vasodilation (EDV). If physiological levels of insulin lead to peripheral, vasodilation and if this vasodilation is an independent determinant of skeletal muscle glucose uptake is however under debate. READ MORE

  6. 4. Glucose and glycerol transport in adipocytes from a structural perspective

    Author : Peng Huang; Medicinsk strukturbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; glucose and glycerol metabolism; glucose transporters; aquaglyceroporins; glucose transporter 4; aquaglyceroporin 7; protein and protein interaction; structure; single particle cryo-EM;

    Abstract : Adipocytes are crucial energy reservoirs to maintain metabolic homeostasis of glucose and lipids in the human body.Glucose transporters (GLUTs) and aquaporins (AQPs) play an important role in metabolic regulation of glucose andlipids in human adipocytes. READ MORE

  7. 5. Impact of glucose uptake rate on recombinant protein production in Escherichia coli

    Author : Emma Bäcklund; Gen Larsson; Olle Holst; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; AIDA-autotransporter; Escherichia coli; fed-batch; glucose uptake rate; integral membrane proteins; outer membrane proteins; periplasmic retention; phosphotransferase system; recombinant proteins; specific growth rate; surface expression; Biology; Biologi;

    Abstract : Escherichia coli (E. coli) is an attractive host for production of recombinant proteins, since it generally provides a rapid and economical means to achieve high product quantities. READ MORE