Search for dissertations about: "glucose-deficiency"

Found 4 swedish dissertations containing the word glucose-deficiency.

  2. 1. Molecular consequences of cellular UDP-glucose deficiency

    Author : Juan Carlos Higuita V; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A Chinese hamster fibroblast mutant cell line, deficient in UDP-glucose (UDPG), denoted as Qc, and its counterpart cell line with normalized levels of UDPG (G3), were used to determine some molecular consequences of chronic UDPG deficiency. The UDPG deficient cells lacked glycogen, had elevated rates of glucose uptake and a decreased capacity to synthesize glycogen after 120h of culture. READ MORE

  4. 2. Effects of arsenic trioxide and hypoxia in multidrug-resistant neuroblastoma

    Author : Jenny Karlsson; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; neuroblastoma; multidrug resistance; hypoxia; glucose-deficiency; cell death; Bax; Apoptosis; arsenic trioxide;

    Abstract : Neuroblastoma is a childhood tumour derived from the sympathetic nervous system. Although most children with neuroblastoma initially respond to treatment, approximately 50% of these patients relapse with multidrug-resistant tumours. Arsenic trioxide (As2O3) has been used for centuries to treat different clinical disorders including malignancies. READ MORE

  5. 3. Energy metabolism and angiogenesis in atherosclerosis and cancer

    Author : Matias Ekstrand; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Hypoxia; Reactive oxygen species; Intussusceptive angiogenesis;

    Abstract : Energy metabolism requires supply of glucose and oxygen. In atherosclerotic plaques and cancer tumors, there are local areas with mismatch in demand and supply of oxygen and nutrients. The resulting cellular energy imbalance may promote energy failure and stimulation of angiogenesis. READ MORE

  6. 4. Hypoxia and differentiation in human neuroblastoma cells

    Author : Helén Nilsson; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ontogeny; embryology human ; Utvecklingsbiologi; teratologi; embryologi människa ; teratology; cytogenetik; Development biology; cytogenetics; Genetik; Genetics; Medicin människa och djur ; HIF; Medicine human and vertebrates ; MYCN; Hypoxia; differentiation; Neuroblastoma;

    Abstract : The childhood tumour neuroblastoma is derived from immature cells of the sympathetic nervous system, which have become arrested at different maturation stages. Neuroblastoma is a malignancy with a high degree of heterogeneity, and there is a correlation between a poor differentiation status and a more aggressive phenotype. READ MORE