Search for dissertations about: "glucuronide"

Showing result 1 - 5 of 26 swedish dissertations containing the word glucuronide.

  2. 1. Chemical Derivatization in Combination with Liquid Chromatography Tandem Mass Spectrometry for Detection and Structural Investigation of Glucuronides

    Author : Matilda Lampinen Salomonsson; Mikael Hedeland; Ulf Bondesson; Calle Nilsson; Uppsala universitet; []
    Keywords : Pharmaceutical chemistry; Derivatization; mass spectrometry; glucuronide; drug metabolism; increased sensitivity; structural investigation; 2-chloro-1-methylpyridinium iodide CMPI ; 1-ethyl-3- 3-dimethylaminopropyl -carbodiimide EDC ; 2-picolylamine PA ; 1; 2-dimethylimidazole-4-sulfonyl chloride DMISC ; Farmaceutisk kemi;

    Abstract : This thesis presents novel approaches for structural investigation of glucuronides using chemical derivatization in combination with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn).Today, LC-ESI-MSn is the dominant technique for quantitative as well as qualitative analyses of metabolites, due to its high sensitivity and selectivity. READ MORE

  4. 2. Drug Metabolites Formed by Cunninghamella Fungi : Mass Spectrometric Characterization and Production for use in Doping Control

    Author : Axel Rydevik; Mikael Hedeland; Ulf Bondesson; David Cowan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cunninghamella blakesleeana; Cunninghamella elegans; Doping Control; Drug Metabolites; Glucuronide Production; Mass Spectrometry; Reactive Metabolites; Reference Material; Structural Characterization; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. The metabolites were characterized with mainly liquid chromatography-mass spectrometry using ion-trap and quadrupole-time-of-flight instruments. A fungal in vitro model has several advantages e.g. READ MORE

  5. 3. Pharmacokinetic and pharmacodynamic studies of morphine and morphine-3-glucuronide in rats : including validation and application of the microdialysis technique and time dependency of antinociceptive effects

    Author : Marianne Ekblom; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  6. 4. Evaluation and clinical application of ethyl glucuronide and ethyl sulfate as biomarkers for recent alcohol consumption

    Author : Helen Dahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In recent years, there has been a growing interest in various biochemical markers for detecting acute and chronic alcohol consumption. Biochemical markers for acute and chronic drinking play important roles in detecting alcohol use, abuse and dependence in hospital settings, work place settings, traffic medicine and in forensic toxicology examinations. READ MORE

  7. 5. Ethyl glucuronide : a new biochemical marker for acute alcohol intake : studies on possible causes for false-negative or false-positive results

    Author : Helen Dahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In recent years, there has been a growing interest in various biochemical markers for detecting acute and chronic alcohol consumption. Biochemical markers for acute and chronic drinking play important roles in detecting alcohol use, abuse and dependence in hospital settings, work place settings, traffic medicine and in forensic toxicology examinations. READ MORE