Search for dissertations about: "glycine-alanine repeat"

Found 4 swedish dissertations containing the words glycine-alanine repeat.

2. 1. Regulation of protein degradation by virus derived repeated amino acid sequences

   Author : Ainars Leonchiks; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Epstein-Barr virus; glycine-alanine repeat; ubiquitin-proteasome pathway;

   Abstract : The ubiquitin-proteasome pathway plays a central role in the controlled degradation of short-lived and regulatory proteins important m a variety of cellular processes, including antigen presentation and combating viral infections. The presentation of antigenic peptides derived from ubiquitin-proteasome dependent degradation of vital proteins to MHC class I restricted cytotoxic T cells is a central component of antiviral responses. READ MORE

4. 2. Regulation of the ubiquitin-proteasome system : characterization of viral and cellular stabilization signals

   Author : Stijn Heessen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Epstein-Barr virus EBV ; glycine-alanine GA repeat; green fluorescent protein GFP ; degron; proteasome; Rad23; ubiquitin; ubiquitin- associated UBA domain;

   Abstract : The ubiquitin-proteasome system plays a fundamental role in virtually every cellular process. Degradation of endogenous proteins by this system is the major source for antigenic peptides that are presented to MHC class I-restricted cytotoxic T cells. READ MORE

5. 3. T-cell mediated control of Epstein-Barr virus infection : viral mechanisms of immune escape

   Author : Jelena Vladmirovna Levitskaya; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Epstein-Barr virus; Cytotoxic T lymphocyte; CTL epitope; viral immunescape;

   Abstract : Mechanisms regulating the immunogenicity of Epstein-Barr Virus (EBV)-encoded CTL peptide epitopes and their contribution to the escape of virus infected cells from CTL-mediated immunosurveillance were the subject of these studies. It was demonstrated that two HLA A11-restricted CTL epitopes of EBV nuclear antigen (EBNA)-4 (designated IVT and AVF) possessed different immunogenicity that appeared to be due to a rapid surface turnover of All molecules containing the AVF peptide. READ MORE

6. 4. Modulation of cellular and viral functions in Epstein-Barr virus infected cells

   Author : Marta P Imreh; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The aim of the study was to investigate the interplay of cellular and viral genes in Epstein-Barr virus (EBV) infected cells. Two aspects of this interaction have been investigated. The first aspect is related to the expression of major histocompatibility complex (MHC) class I molecules in virus infected malignant cells. READ MORE