Search for dissertations about: "go no-go"

Showing result 1 - 5 of 8 swedish dissertations containing the words go no-go.

  2. 1. Change in the Pharmaceutical Industry : Aspects on Innovation, Entrepreneurship, Openness, and Decision Making

    Author : Thomas Hedner; Magnus Klofsten; Johan Braet; Mirjam Knockaert; Linköpings universitet; []
    Keywords : Pharmaceutical industry; Big Pharma; life sciences; drug discovery; drug development; R D; business model; innovation; closed innovation; open innovation; entrepreneurship; intellectual property; multiple stakeholders; decision making; judgment; uncertainty; go no-go; go no-go recycle; company; SME.; Läkemedelsindustri; Big Pharma; biovetenskap; läkemedelsutveckling; utveckling av läkemedel; FoU; affärsmodell; innovation; stängd innovation; öppen innovation; entreprenörskap; immaterialrätt; beslutsfattande; osäkerhet; go no-go; go no-go recycle; företag; små och medelstora företag;

    Abstract : Over the past century, the pharmaceutical industry has been a major contributor of individual and population health and societal wealth. Its products and services have contributed to longevity of large groups of patients and symptom relief from major diseases. READ MORE

  4. 2. Children's lived rights : The everyday politics of asylum-seeking children

    Author : Sandra Karlsson; Karin Aronsson; Mats Trondman; Nihad Bunar; Anna Lundberg; Stockholms universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; everyday politics; asylum politics; deportability; no-go zones; lived rights; lived fears; politics of play; agency; navigation; play tactics; belonging; emotions; articulations; standpoints; home; regulations; ethnography; children’s geographies; barn- och ungdomsvetenskap; Child and Youth Studies;

    Abstract : This thesis explores asylum-seeking children’s everyday politics in relation to their situation in the Swedish reception system. It engages in a theorization of children’s political agency in which a broad definition of politics is adopted to examine and acknowledge the politics embedded in children’s everyday spaces and children’s everyday actions. READ MORE

  5. 3. Drug research and development - case scenarios, development process, risks and benefits

    Author : Ivor Cowlrick; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery and development; benefit and risk; decision making; entrepreneurship; open innovation;

    Abstract : BACKGROUND AND AIMS. Drug development has been classically associated with large pharmaceutical companies developing ‘blockbuster’ drugs aimed at large patient populations through high market penetration and multiple indication life cycle management. Higher costs and lower output have rendered this model inefficient and unsustainable. READ MORE

  6. 4. Structure-Dynamics relationship in basalganglia: Implications for brain function

    Author : Jyotika Bahuguna; Arvind Kumar; Jeanette Kotaleski; Nicholas Mallet; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Computational Modeling; Basal ganglia; network dynamics; Computer Science; Datalogi;

    Abstract : In this thesis, I have used a combination of computational models such as mean field and spikingnetwork simulations to study various sub-circuits of basal ganglia. I first studied the striatum(chapter 2), which is the input nucleus of basal ganglia. READ MORE

  7. 5. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data

    Author : Gustaf Wellhagen; Maria C. Kjellsson; Bengt Hamrén; Per Olsson Gisleskog; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; modelling; non-linear mixed effects modelling; composite scale data; total score data; total score analysis; precision prediction; bounded integer; bounded integer model; IRT-informed total score analysis; item response theory-informed; mixed models for repeated measures; MMRM; dose-response; dose-response mixed models for repeated measures; DR-MMRM; HbA1c models; fit-for-purpose analysis; clinical trial analysis; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. READ MORE